| CPC C07D 413/04 (2013.01) [C07D 405/04 (2013.01); C07D 413/14 (2013.01)] | 25 Claims |
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1. A compound of formula (I)
 wherein:
Ra1, Ra2, Ra3, Ra4, Ra5, and Ra6 are independently selected from the group consisting of H, a halogen, C1-4 alkyl, and A2a, wherein C1-4 alkyl is unsubstituted or substituted with substituents selected from the group consisting of a halogen, OH, and O—C1-3 alkyl, and wherein only one of Ra1, Ra2, Ra3, Ra4, Ra5, and Ra6 is A2a;
ring A1 is C5 cycloalkylene, C5 cycloalkenylene, or a nitrogen-containing 5-membered heterocyclene where the atom of ring A1 marked with an asterisk is a carbon atom, and wherein ring A1 is unsubstituted or substituted with one or more R4;
each R4 is independently oxo (═O), thiooxo (═S), a halogen, CN, OR5, or C1-6 alkyl, wherein each C1-6 alkyl is independently unsubstituted or substituted with one or more halogen, which are the same or different;
R5 is H or C1-6 alkyl that is unsubstituted or substituted with one or more halogen, which are the same or different;
A2 is R6a or A2a;
R6a is OR6a1, SR6a1, N(R6a1R6a2), C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more substituents selected from the group consisting of a halogen, OR6a3, CN, and A2a, wherein the substituents are the same or different;
R6a1 and R6a2 are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and A2a, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more substituents selected from the group consisting of a halogen, CN, OR6a3, A2a, and OA2a, wherein the substituents are the same or different;
R6a3 is H or C1-4 alkyl, wherein C1-4 alkyl is unsubstituted or substituted with one or more halogen, which are the same or different;
each A2a is independently phenyl, C3-7 cycloalkyl, C4-12 bicycloalkyl, or 3- to 7-membered heterocyclyl, wherein each A2a is independently unsubstituted or substituted with one or more R6, which are the same or different;
each R6 is independently R6b, OH, OR6b, a halogen, or CN, wherein each R6b is independently cyclopropyl, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, wherein each R6b is independently unsubstituted or substituted with one or more halogen, which are the same or different, or two R6 are joined together with the atoms to which they are attached to form a ring A2b;
A2b is independently phenyl, C3-7 cycloalkyl, or a 3- to 7-membered heterocyclyl, wherein A2b is independently unsubstituted or substituted with one or more R7, which are the same or different;
each R7 is independently C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are independently unsubstituted or substituted with one or more halogen, which are the same or different;
R1 is H or C1-4 alkyl, wherein C1-4 alkyl is unsubstituted or substituted with one or more halogen, which are the same or different;
R2 is H, F, or C1-4 alkyl, wherein C1-4 alkyl is unsubstituted or substituted with one or more halogen, which are the same or different, and R3 is A3, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more R8, which are the same or different, or R2 and R3 are joined together with the oxygen atom and carbon atom to which they are attached to form a ring A3a, wherein ring A3a is a 7- to 12-membered heterobicyclyl, wherein the 7- to 12-membered heterobicyclyl is unsubstituted or substituted with one or more R10, which are the same or different;
R2a is H or F;
each R8 is independently a halogen, CN, C(O)OR9, OR9, C(O)R9, C(O)N(R9R9a), S(O)2N(R9R9a), S(O)N(R9R9a), S(O)2R9, S(O)R9, N(R9)S(O)2N(R9aR9b), SR9, N(R9R9a), NO2, OC(O)R9, N(R9)C(O)R9, N(R)SO2R9a, N(R9)S(O)R9a, N(R9)C(O)N(R9aR9b), N(R9)C(O)OR9a, OC(O)N(R9R9a), or A3;
each R9, R9a, and R9b are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more halogen, which are the same or different, or one OH, or one OC1-4 alkyl, or one A3;
each A3 is independently phenyl, naphthyl, C3-7 cycloalkyl, a 3-to-7 membered heterocyclyl, or a 7- to 12-membered heterobicyclyl, wherein each A3 is independently unsubstituted or substituted with one or more R10, which are the same or different;
each R10 is independently a halogen, CN, C(O)OR11, OR11, C(O)R11, C(O)N(R11R11a), S(O)2N(R11R11a), S(O)N(R11R11a), S(O)2R11, S(O)R11, N(R11)S(O)2N(R11aR11b), SR11, N(R11R11a), NO2, OC(O)R11, N(R11) C(O)R11a, N(R11)SO)2R11a, N(R11)S(O)R11a, N(R11)C(O)OR11a, N(R11)C(O)N(R11aR11b), OC(O)N(R11R11a), oxo (═O), C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more R12, which are the same or different;
each R11, R11a, and R11b are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more halogen, which are the same or different;
each R12 is independently a halogen, CN, C(O)OR13, OR13, C(O)R13, C(O)N(R13R13a), S(O)2N(R13R13a), S(O)N(R13R13a), S(O)2R13, S(O)R13, N(R13)S(O)2N(R13aR13b), SR13, N(R13R13a), NO2, OC(O)R13, N(R13) C(O)R13a, N(R13)SO2R13a, N(R13)S(O)R13a, N(R13)C(O)N(R13aR13b), N(R13)C(O)OR13a, or OC(O)N(R13R13a); and
each R13, R13a, and R13b are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are unsubstituted or substituted with one or more halogen, which are the same or different.
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