US 12,441,693 B2
Targeting STAT sumoylation to enhance immune responses
Alberto Bosque-Pardos, Washington, DC (US); Amanda Beatriz Rodrigues Barreto De Macedo, Washington, DC (US); Eric S. Sorensen, Washington, DC (US); and Vicente Planelles, Salt Lake City, UT (US)
Assigned to The George Washington University, Washington, DC (US); and University of Utah Research Foundation, Salt Lake City, UT (US)
Filed by THE GEORGE WASHINGTON UNIVERSITY, Washington, DC (US); and University of Utah Research Foundation, Salt Lake City, UT (US)
Filed on Dec. 17, 2020, as Appl. No. 17/125,900.
Application 17/125,900 is a continuation of application No. PCT/US2019/039336, filed on Jun. 26, 2019.
Claims priority of provisional application 62/799,524, filed on Jan. 31, 2019.
Claims priority of provisional application 62/690,629, filed on Jun. 27, 2018.
Prior Publication US 2021/0114999 A1, Apr. 22, 2021
Int. Cl. C07D 255/02 (2006.01); A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/42 (2025.01); A61K 40/46 (2025.01); C12N 5/0783 (2010.01); A61K 40/50 (2025.01); C07K 14/54 (2006.01); C07K 14/55 (2006.01)
CPC C07D 255/02 (2013.01) [A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/42 (2025.01); A61K 40/46 (2025.01); C12N 5/0636 (2013.01); A61K 40/50 (2025.01); A61K 2239/48 (2023.05); C07K 14/5418 (2013.01); C07K 14/5434 (2013.01); C07K 14/5443 (2013.01); C07K 14/55 (2013.01)] 8 Claims
 
1. A method of treating a subject having cancer, the method comprising:
contacting for a pre-determined time one or more isolated immune cells with a compound consisting of

OG Complex Work Unit Chemistry
and
administering to a subject having cancer a therapeutically effective amount of the one or more isolated immune cells contacted with the compound.