US 12,441,615 B2
Method of administering nitric oxide gas
Ronald Kramer, Signal Hill, CA (US); and Alexandros Nikolaidis, Nea Kallikratia (GR)
Assigned to ThermoLife International, LLC, Signal Hill, CA (US)
Filed by ThermoLife International, LLC, Signal Hill, CA (US)
Filed on Feb. 11, 2022, as Appl. No. 17/670,383.
Application 17/670,383 is a continuation of application No. PCT/US2022/016231, filed on Feb. 11, 2022.
Claims priority of provisional application 63/148,523, filed on Feb. 11, 2021.
Claims priority of provisional application 63/180,039, filed on Apr. 26, 2021.
Prior Publication US 2022/0249796 A1, Aug. 11, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 33/00 (2006.01); A61K 9/00 (2006.01); A61K 33/06 (2006.01); A61M 16/10 (2006.01); A61M 16/12 (2006.01); A61P 11/00 (2006.01); A61P 11/08 (2006.01); C01B 21/24 (2006.01)
CPC C01B 21/24 (2013.01) [A61K 9/007 (2013.01); A61K 33/00 (2013.01); A61M 16/10 (2013.01); A61M 16/12 (2013.01); A61P 11/00 (2018.01); A61P 11/08 (2018.01); A61M 2202/0275 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method of administering NO inhalation therapy, the method comprising:
providing a vessel capable of housing liquid and gaseous constituents, wherein the vessel contains an acidic solution having a pH of 0.1-4;
combining an effective amount of a nitrate salt and an effective amount of an elemental metal capable of being oxidized in the acidic solution in the vessel thereby producing NO gas and H2 gas, wherein the gas constituents produced by combining the nitrate salt and the elemental metal in the acidic solution do not comprise unsafe levels of NO2 gas for humans in the presence of oxygen; and
administering the gas constituents produced to a human subject via the vessel capable of housing liquid and gas constituents.