US 12,440,843 B2
Apparatus and a method for ex-vivo measurement of performance of a donor heart
Foppe Nijhuis, Garijp (NL); Arjan Van Der Plaats, Meeden (NL); and Michiel Elardus Erasmus, Groningen (NL)
Assigned to XVIVO HOLDING B.V., Groningen (NL); RIJKSUNIVERSITEIT GRONINGEN, Groningen (NL); and ACADEMISCH ZIEKENHUIS GRONINGEN, Groningen (NL)
Appl. No. 17/421,114
Filed by Organ Assist B.V., Groningen (NL); Rijksuniversiteit Groningen, Groningen (NL); and Academisch Ziekenhuis Groningen, Groningen (NL)
PCT Filed Jan. 10, 2019, PCT No. PCT/NL2019/050013
§ 371(c)(1), (2) Date Jul. 7, 2021,
PCT Pub. No. WO2020/145814, PCT Pub. Date Jul. 16, 2020.
Prior Publication US 2022/0152607 A1, May 19, 2022
Int. Cl. A01N 1/143 (2025.01); B01L 3/00 (2006.01)
CPC B01L 3/505 (2013.01) [A01N 1/143 (2025.01); B01L 2200/026 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/14 (2013.01); B01L 2400/0403 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An apparatus for ex-vivo measurement of performance of a human donor heart, comprising:
a heart holder in a receptacle for holding the human donor heart ex vivo in the heart holder;
a perfusion fluid supply conduit extending into the receptacle with a connector for connection to the human donor heart;
a perfusion discharge conduit communicating with the interior space of the receptacle for collection of perfusion fluid drained from the human donor heart;
a perfusion pump and an oxygenator connected between the perfusion fluid supply conduit and the perfusion discharge conduit;
a bag for placement into a left ventricle of the human donor heart, the bag having a bag interior space;
a fluid tight, compressible and expandable container having a container interior space communicating with the bag interior space;
a sensor for measuring compression and expansion of the container; and
an actuator for exerting a compression force on the container and an actuator control for varying the compression force;
wherein the actuator and the actuator control are configured for controlling a preload pressure or fluid displacement or flow driving a fluid transfer from the container into the bag, wherein the actuator and the actuator control are configured for at least controlling the preload pressure or fluid displacement or flow by:
controlling a force urging the container into compression in accordance with a measured rate of compression or expansion of the container and with at least one predetermined fluidic impedance value, and/or
controlling a rate of compression or expansion of the container in accordance with at least measured force urging the container into compression or a measured pressure in the container or in the bag and with at least one predetermined fluidic impedance value.