US 12,440,840 B2
Contactless selection device, light sensing structure thereof, and biological particle selection apparatus
Chung-Er Huang, Hsinchu County (TW); Sheng-Wen Chen, Hsinchu County (TW); and Hsin-Cheng Ho, Hsinchu County (TW)
Assigned to CYTOAURORA BIOTECHNOLOGIES, INC., Hsinchu County (TW)
Filed by CYTOAURORA BIOTECHNOLOGIES, INC., Hsinchu County (TW)
Filed on Nov. 16, 2022, as Appl. No. 17/987,978.
Claims priority of application No. 111129949 (TW), filed on Aug. 10, 2022.
Prior Publication US 2024/0050948 A1, Feb. 15, 2024
Int. Cl. B01L 3/00 (2006.01); B03C 5/00 (2006.01)
CPC B01L 3/502761 (2013.01) [B01L 3/502715 (2013.01); B03C 5/005 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0645 (2013.01); B01L 2400/0424 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A biological particle selection apparatus for selecting a target biological particle from a liquid specimen, the biological particle selection apparatus comprising:
a contactless selection device including:
a light sensing structure including:
a first substrate;
a first electrode layer formed on one side of the first substrate;
a photoelectric layer formed on another side of the first substrate and including:
a collector layer formed on the first substrate, wherein the collector layer includes a plurality of collector regions spaced apart from each other, and an end of each of the collector regions away from the first electrode layer has a first slot-like portion;
a plurality of base regions respectively formed in the first slot-like portions of the collector regions, wherein an end of each of the base regions away from the first electrode layer has a plurality of second slot-like portions spaced apart from each other; and
a plurality of emitter regions respectively formed in the base regions, wherein each of the emitter regions includes a plurality of emitter pads respectively formed in the second slot-like portions of a corresponding one of the base regions, and wherein each of the base regions, a corresponding one of the collector regions, and a corresponding one of the emitter regions are jointly formed as a vertical transistor; and
an insulating layer covering the vertical transistors and separating the vertical transistors from each other, wherein an end of each of the emitter pads away from the first electrode layer is exposed from the insulating layer; and
a mating structure spaced apart from the light sensing structure, wherein at least one of the mating structure and the light sensing structure is transparent, and the mating structure includes a second substrate and a second electrode layer that is formed on the second substrate and that faces toward the light sensing structure; and
an alternating current (AC) power device electrically coupled to the first electrode layer and the second electrode layer;
wherein, when the liquid specimen is located between the insulating layer and the second electrode layer of the contactless selection device, any one of the vertical transistors of the contactless selection device is configured to be irradiated by a light source so as to enable a plurality of dielectrophoresis (DEP) forces to be applied to move the target biological particle through a distribution of the emitter pads and an electric field difference that is generated in the liquid specimen from non-uniform electric fields of the emitter pads.