US 12,440,697 B2
Systems and methods for phototherapeutic modulation of nitric oxide
Nathan Stasko, Chapel Hill, NC (US); Nicholas William Medendorp, Jr., Carmel, IN (US); Gerald H. Negley, Chapel Hill, NC (US); and Katelyn P. Reighard, Chapel Hill, NC (US)
Assigned to KNOW Bio, LLC, Durham, NC (US)
Filed by KNOW Bio, LLC, Morrisville, NC (US)
Filed on Mar. 9, 2023, as Appl. No. 18/181,079.
Application 18/181,079 is a continuation of application No. 16/898,385, filed on Jun. 10, 2020, granted, now 11,617,895.
Application 16/898,385 is a continuation of application No. 16/709,550, filed on Dec. 10, 2019, granted, now 11,524,173, issued on Dec. 13, 2022.
Application 16/709,550 is a continuation of application No. 15/222,199, filed on Jul. 28, 2016, granted, now 10,525,275, issued on Jan. 7, 2020.
Claims priority of provisional application 62/197,746, filed on Jul. 28, 2015.
Prior Publication US 2023/0211174 A1, Jul. 6, 2023
Int. Cl. A61N 5/06 (2006.01); H10H 29/10 (2025.01)
CPC A61N 5/0613 (2013.01) [A61N 5/0601 (2013.01); A61N 5/0603 (2013.01); A61N 5/0624 (2013.01); H10H 29/10 (2025.01); A61N 2005/0611 (2013.01); A61N 2005/0626 (2013.01); A61N 2005/0629 (2013.01); A61N 2005/0647 (2013.01); A61N 2005/0652 (2013.01); A61N 2005/0653 (2013.01); A61N 2005/0659 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/0662 (2013.01); A61N 2005/0663 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method comprising:
impinging light having a first peak wavelength on tissue during a first time window, and an intensity of the light having the first peak wavelength decreases to a reduced non-zero value during the first time window;
impinging light having a second peak wavelength on the tissue during a second time window; and
impinging light having a third peak wavelength on the tissue;
wherein the second peak wavelength differs from the first peak wavelength by at least 25 nanometers (nm);
wherein the third peak wavelength differs from each of the first peak wavelength and the second peak wavelength by at least 10 nm; and
wherein the first time window and the second time window are non-overlapping with one another, and the first time window is devoid of the second peak wavelength.