US 12,440,695 B2
Systems and methods to enhance memory using non-invasive brain stimulation
Emiliano Santarnecchi, Brookline, MA (US); and Giacomo Koch, Rome (IT)
Assigned to Sinaptica Therapeutics, Inc., Cambridge, MA (US)
Filed by Sinaptica Therapeutics, Inc., Cambridge, MA (US)
Filed on Oct. 31, 2024, as Appl. No. 18/933,030.
Application 18/933,030 is a continuation of application No. PCT/US2023/069421, filed on Jun. 29, 2023.
Claims priority of provisional application 63/356,609, filed on Jun. 29, 2022.
Prior Publication US 2025/0121201 A1, Apr. 17, 2025
Int. Cl. A61N 2/00 (2006.01); A61B 5/00 (2006.01); A61B 5/242 (2021.01); A61B 5/245 (2021.01); A61B 5/377 (2021.01); A61B 5/388 (2021.01); A61B 5/389 (2021.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01); A61N 2/02 (2006.01); G16H 20/30 (2018.01); G16H 20/70 (2018.01); G16H 30/40 (2018.01); G16H 40/63 (2018.01); G16H 50/20 (2018.01); G16H 50/50 (2018.01)
CPC A61N 2/002 (2013.01) [A61N 1/0408 (2013.01); A61N 1/36025 (2013.01); A61N 1/36031 (2017.08); A61N 1/36034 (2017.08); A61N 2/006 (2013.01); A61N 2/02 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of enhancing memory in a subject, the method comprising:
applying to a first brain region in a brain of a subject, during a first time period, a combination of transcranial magnetic stimulation (TMS) and transcranial alternating current stimulation (tACS), wherein
the first brain region represents a functional brain network associated with memory;
the tACS is applied using a target frequency in a gamma frequency range, and applying to the first brain region in a brain of a subject, during a first time period, a combination of TMS and tACS comprises:
continuously applying tACS during the first time period as a sinusoidal wave; and
applying TMS as a set of stimulation pulse trains separated by periods of non-stimulation.