	US 12,440,680 B2
	Methods of treating disease by skewing macrophage phenotype with alternating electric fields
Tali Voloshin-Sela, Kibbutz Gvat (IL); Lilach Avigdor, Haifa (IL); and Boris Brant, Haifa (IL)
Assigned to Novocure GmbH, Baar (CH)
Filed by Novocure GmbH, Root (CH)
Filed on Mar. 11, 2022, as Appl. No. 17/692,807.
Claims priority of provisional application 63/160,437, filed on Mar. 12, 2021.
Prior Publication US 2022/0288395 A1, Sep. 15, 2022
Int. Cl. A61N 1/00 (2006.01); A61K 45/06 (2006.01); A61N 1/36 (2006.01)

CPC A61N 1/36171 (2013.01) [A61K 45/06 (2013.01); A61N 1/36007 (2013.01); A61N 1/3601 (2013.01)]

5 Claims

1. A method of treating an infection in a subject, comprising:

applying alternating electric fields of frequency between 50 and 500 kHz and field strength of 0.1 to 10 V/cm to the subject; and

administering a therapeutically effective amount of an antibiotic for treating the infection to the subject; wherein the infection is with:

Tropheryma whipplei, or Salmonella in a digestive system and the alternating electric fields are applied to the digestive system of the subject.