| CPC A61N 1/36139 (2013.01) [A61N 1/36171 (2013.01)] | 21 Claims |

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1. A method of cycling electric stimulation, the method comprising:
delivering, via an implantable device, electric stimulation to a patient in accordance with a first therapy program;
monitoring, via the implantable device and while the electric stimulation is being delivered in accordance with the first therapy program, a biomarker;
responsive to determining the biomarker satisfies a threshold, delivering, via the implantable device, electric stimulation to the patient in accordance with a second therapy program that is different than the first therapy program; and
responsive to determining the biomarker does not satisfy the threshold after delivering the electrical stimulation in accordance with the second therapy program, delivering, via the implantable device, electric stimulation to the patient in accordance with the first therapy program.
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