US 12,440,672 B2
Systems and methods for sustained relief of chronic pain
Nathan D. Crosby, Cleveland, OH (US); Isaac R. Cassar, Cleveland, OH (US); and Joseph W. Boggs, II, Chapel Hill, NC (US)
Assigned to SPR THERAPEUTICS, INC., Cleveland, OH (US)
Appl. No. 17/629,428
Filed by SPR THERAPEUTICS, INC., Cleveland, OH (US)
PCT Filed Jul. 27, 2020, PCT No. PCT/US2020/043709
§ 371(c)(1), (2) Date Jan. 24, 2022,
PCT Pub. No. WO2021/016616, PCT Pub. Date Jan. 28, 2021.
Claims priority of provisional application 63/050,265, filed on Jul. 10, 2020.
Claims priority of provisional application 62/944,711, filed on Dec. 6, 2019.
Claims priority of provisional application 62/935,207, filed on Nov. 14, 2019.
Claims priority of provisional application 62/878,522, filed on Jul. 25, 2019.
Prior Publication US 2022/0241589 A1, Aug. 4, 2022
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36021 (2013.01) [A61N 1/0502 (2013.01); A61N 1/0551 (2013.01); A61N 1/36017 (2013.01); A61N 1/36031 (2017.08); A61N 1/36034 (2017.08)] 14 Claims
OG exemplary drawing
 
1. A method to provide relief of pain, the method comprising:
inserting at least one percutaneous lead having at least one stimulating electrode and at least one recording electrode formed integrally on the lead, wherein the stimulating electrode is positioned on an anchor of the at least one percutaneous lead;
stimulating at least one peripheral nerve that innervates a region of pain using an electrical stimulation device operatively coupled to the lead to create comfortable sensations in the region of pain;
positioning the stimulating electrode to within a therapeutically effective distance from at least one target peripheral nerve independent of a distance from a nerve using analysis of recorded neural and/or muscle feedback, wherein the therapeutically effective distance comprises 0.5 to 3 cm; and
applying stimulation parameters to optimize activation of a sufficient number of target peripheral nerve fibers to produce relief of pain, wherein the stimulation parameters are informed by analysis of recorded peripheral neural and/or muscle feedback, wherein the recorded neural and/or muscle activity indicates an optimal or non-optimal response to stimulation;
wherein the neural activity is a compound action potential and the optimal response is a compound action potential of magnitude that indicates activation of a sufficient number of large diameter sensory afferent fibers.