US 12,440,622 B2
Devices and methods for overfilling drug containers
Daniel B. Dix, Fort Myers, FL (US); Douglas Kamen, Poughquag, NY (US); and Kenneth Graham, Pleasant Valley, NY (US)
Assigned to Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed by Regeneron Pharmaceuticals Inc., Tarrytown, NY (US)
Filed on Jan. 26, 2024, as Appl. No. 18/424,037.
Application 18/424,037 is a continuation of application No. 18/152,431, filed on Jan. 10, 2023, granted, now 11,918,785.
Application 18/152,431 is a continuation of application No. 16/626,677, granted, now 11,577,025, issued on Feb. 14, 2023, previously published as PCT/US2017/040011, filed on Jun. 29, 2017.
Prior Publication US 2024/0207516 A1, Jun. 27, 2024
Int. Cl. A61M 5/178 (2006.01); B65B 3/00 (2006.01)
CPC A61M 5/1782 (2013.01) [B65B 3/003 (2013.01); A61M 2202/30 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A drug product, comprising:
a primary packaging component having a nominal volume, wherein the primary packaging component includes a body and a flange;
a volume of formulated drug substance in the primary packaging component, wherein the volume of formulated drug substance is greater than the nominal volume, and wherein the volume of formulated drug substance is within an interior of the body of the primary packaging component;
a stopper, wherein the stopper is sized and configured to fit snugly within a wall of the interior of the body; and
a plunger rod connected to the stopper,
wherein the stopper is positioned within the primary packaging component at a stopper position that is at a distance distal to the flange that restricts the plunger rod from tilting to deform the stopper to an extent that compromises a seal formed by the stopper.