US 12,440,614 B2
System and method for producing fluid for peritoneal dialysis
Christian Vartia, Veberod (SE); Henrik Lindgren, Genarp (SE); Per-Olof Borgqvist, Lund (SE); and Olof Jansson, Vellinge (SE)
Assigned to GAMBRO LUNDIA AB, Lund (SE)
Appl. No. 17/798,114
Filed by Gambro Lundia AB, Lund (SE)
PCT Filed Feb. 5, 2021, PCT No. PCT/EP2021/052784
§ 371(c)(1), (2) Date Aug. 8, 2022,
PCT Pub. No. WO2021/156429, PCT Pub. Date Aug. 12, 2021.
Claims priority of application No. 2050127-6 (SE), filed on Feb. 6, 2020.
Prior Publication US 2023/0069896 A1, Mar. 9, 2023
Int. Cl. A61M 1/28 (2006.01); A61M 1/16 (2006.01); B01D 61/00 (2006.01)
CPC A61M 1/287 (2013.01) [A61M 1/1672 (2014.02); A61M 1/284 (2014.02); B01D 61/002 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for producing fluid for peritoneal dialysis (PD), the system comprising:
a fluid path including one or more PD-concentrate connectors each connector configured to be connected to a source of PD concentrate fluid, an inlet connector configured to be connected to a fluid line arranged for transportation of effluent fluid from a patient;
a forward osmosis (FO)-unit including a draw side and a feed side separated by a FO-membrane, the FO-unit fluidly connected to the fluid path, wherein the FO-unit is configured to receive one or more PD concentrate fluids at the draw side and to receive the effluent at the feed side, wherein water is transported from the effluent to the one or more PD concentrate fluids through the FO-membrane via an osmotic pressure gradient between the draw side and the feed side, thereby diluting the one or more PD concentrate fluids into a diluted PD concentrate fluid, wherein the fluid path includes a circulation fluid path for circulating the diluted PD concentrate fluid;
a concentration sensor configured to sense the concentration of the diluted PD concentrate fluid; and
a control arrangement configured to
control a flow rate of effluent fluid into the feed side, and control a flow rate of the one or more PD concentrate fluids into the draw side based on a desired composition of a final PD fluid, a concentration of the one or more PD concentrate fluids, an amount of effluent at hand, and a time available for an FO session to yield the diluted PD concentrate fluid,
circulate the diluted PD concentrate fluid in the circulation fluid path until a mixing criterion for the diluted PD concentrate fluid is fulfilled based on the sensed concentration by the concentration sensor, and
control a flow rate of a second or third concentrate into the diluted PD concentrate fluid to form the final PD fluid.