US 12,440,613 B2
System, computer system and computer program for determining a cardiovascular parameter
Sergej Kammerzell, Munich (DE); Mark Konrad, Munich (DE); and Maarten Willem Nicolaas Nijsten, Groningen (NL)
Assigned to Pulsion Medical Systems SE, Feldkirchen (DE)
Appl. No. 17/427,075
Filed by PULSION MEDICAL SYSTEMS SE, Feldkirchen (DE)
PCT Filed Jan. 30, 2020, PCT No. PCT/EP2020/052337
§ 371(c)(1), (2) Date Jul. 29, 2021,
PCT Pub. No. WO2020/157225, PCT Pub. Date Aug. 6, 2020.
Claims priority of application No. 102019000730.1 (DE), filed on Jan. 31, 2019.
Prior Publication US 2022/0096722 A1, Mar. 31, 2022
Int. Cl. A61M 1/16 (2006.01); A61M 1/36 (2006.01); G16H 40/63 (2018.01)
CPC A61M 1/1698 (2013.01) [A61M 1/1617 (2014.02); A61M 1/3609 (2014.02); A61M 1/3623 (2022.05); G16H 40/63 (2018.01); A61M 2205/3368 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for determining a cardiovascular parameter in a patient, wherein the system is adapted to work in conjunction with an extracorporeal blood treatment device (ECBTD) connectable to a patient's vascular system via an afferent line and an efferent line, wherein the ECBTD comprises a first circuit with at least one pump arranged between the afferent and the efferent line for pumping the blood of the patient,
the system comprising:
a) a liquid-filled, second circuit thermally connected to the first circuit of the ECBTD via a heat exchanger,
b) a temperature changing device for generating a controlled temperature change in the second circuit,
c) a temperature sensor TS2up arranged in the second circuit upstream of the heat exchanger, and a temperature sensor TS2down arranged in the second circuit downstream of the heat exchanger,
d) a computer system connected to the temperature sensors TS2up and TS2down and to the temperature changing device, which is adapted to induce a temperature change within the first circuit of the ECBTD via the temperature changing device, to record each temperature as a function of time and to evaluate the respective temperature curves T2up(t) and T2down(t), wherein the computer system is further adapted to compute a relation of T2up(t) and T2down(t)1 in order to determine and control the characteristics of the time-dependent changes in the temperature generated by the temperature changing device, wherein T2down(t)1 is derived from temperature data measured by TS2down in a first time frame, and to determine the cardiovascular parameter of the patient from the relation of T2up(t) and T2down(t)2), wherein T2down(t)2 is derived from temperature data measured by TS2down in a second time frame that is different from the first time frame.