US 12,440,612 B2
PH and buffer management system for hemodialysis systems
Bryant J. Pudil, Plymouth, MN (US); Martin T. Gerber, Maple Grove, MN (US); David B. Lura, Maple Grove, MN (US); and Thomas E. Meyer, Stillwater, MN (US)
Assigned to MOZARC MEDICAL US LLC, Minneapolis, MN (US)
Filed by MOZARC MEDICAL US LLC, Minneapolis, MN (US)
Filed on Oct. 26, 2022, as Appl. No. 17/974,484.
Application 17/974,484 is a continuation of application No. 13/757,792, filed on Feb. 2, 2013, abandoned.
Claims priority of provisional application 61/735,380, filed on Dec. 10, 2012.
Prior Publication US 2023/0123024 A1, Apr. 20, 2023
Int. Cl. A61M 1/16 (2006.01); A61M 1/28 (2006.01); A61M 1/34 (2006.01)
CPC A61M 1/1696 (2013.01) [A61M 1/1605 (2014.02); A61M 1/287 (2013.01); A61M 1/3406 (2014.02); A61M 1/165 (2014.02); A61M 1/34 (2013.01); A61M 1/3413 (2013.01); A61M 1/3437 (2014.02); A61M 2205/33 (2013.01); A61M 2205/3324 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A system comprising:
a dialysate flow loop for circulating a dialysate through a dialyzer,
wherein the dialysate flow loop comprises a dialysate regeneration unit having a sorbent cartridge;
a pH-buffer management system for adding or generating a pH-buffer modifying solution to the dialysate,
wherein the pH-buffer modifyinq solution has a different pH from the dialysate;
wherein the pH-buffer management system comprises a bipolar electrodialysis system for at least acidifying the dialysate;
a degasser module configured to remove at least carbon dioxide generated by the bipolar electrodialysis system; and
a controller programmed for calculating an amount of the pH-buffer modifying solution for addition to the dialysate to adjust the dialysate to be of a predetermined pH and bicarbonate buffer concentration,
wherein the controller is further programmed to determine an amount of bicarbonate generated by the dialysate regeneration unit due to a urea concentration of the dialysate upstream of the dialysate regeneration unit.