US 12,440,610 B2
Coated medical devices and methods of inhibiting implant-associated infections
Aaron Seitz, Cincinnati, OH (US); Michael Edwards, Cincinnati, OH (US); Erich Gulbins, Cincinnati, OH (US); and Ryan Gobble, Cincinnati, OH (US)
Assigned to University of Cincinnati, Cincinnati, OH (US)
Filed by UNIVERSITY OF CINCINNATI, Cincinnati, OH (US)
Filed on Jul. 12, 2022, as Appl. No. 17/863,068.
Application 17/863,068 is a division of application No. 16/758,508, granted, now 11,517,650, previously published as PCT/US2018/057282, filed on Oct. 24, 2018.
Claims priority of provisional application 62/576,243, filed on Oct. 24, 2017.
Prior Publication US 2022/0339328 A1, Oct. 27, 2022
Int. Cl. A61L 31/16 (2006.01); A61L 27/54 (2006.01)
CPC A61L 31/16 (2013.01) [A61L 27/54 (2013.01); A61L 2300/406 (2013.01); A61L 2300/606 (2013.01); A61L 2420/02 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A medical device comprising an antibiotic coating, said coating formed by applying to the device a saturated or supersaturated solution of one or more antibiotics in a fast-evaporating or medium-evaporating organic solvent, wherein:
the saturated or supersaturated solution is prepared by applying energy to an admixture of the antibiotic in the fast-evaporating or medium-evaporating organic solvent;
applying comprises one or more applications, each application followed directly by evaporating residual organic solvent;
the fast-evaporating organic solvent exhibits a vaporization rate under ambient conditions of greater than 3 based on an n-butyl acetate standard=1; and
the medium-evaporating organic solvent exhibits a vaporization rate under ambient conditions of between 0.8 and 3.0, inclusive, based on an n-butyl acetate standard=1.