US 12,440,608 B2
Polyurethane composite sheet, a method of making such composite sheet, and use thereof in making a medical implant
Noel L. Davison, Echt (NL); Mandy Maria Jozefina Wiermans, Echt (NL); Nicolaes Hubertus Maria De Bont, Echt (NL); and Mark Kenneth Hazzard, Echt (NL)
Assigned to DSM IP ASSETS B.V., Maastricht (NL)
Appl. No. 18/023,801
Filed by DSM IP Assets B.V., Heerlen (NL)
PCT Filed Aug. 30, 2021, PCT No. PCT/EP2021/073912
§ 371(c)(1), (2) Date Feb. 28, 2023,
PCT Pub. No. WO2022/049038, PCT Pub. Date Mar. 10, 2022.
Claims priority of application No. 20193942 (EP), filed on Sep. 1, 2020.
Prior Publication US 2023/0310718 A1, Oct. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/06 (2006.01); A61L 31/14 (2006.01); C08L 75/04 (2006.01); D06N 3/14 (2006.01)
CPC A61L 31/06 (2013.01) [A61L 31/14 (2013.01); C08L 75/04 (2013.01); D06N 3/14 (2013.01); A61L 2400/18 (2013.01); C08L 2201/06 (2013.01); C08L 2203/02 (2013.01); C08L 2203/16 (2013.01); D06N 2201/0254 (2013.01); D06N 2203/068 (2013.01); D06N 2211/18 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A polyurethane composite sheet comprising:
a fabric comprised of braided or woven strands of biocompatible, high-strength polymer fibers, the fabric having a thickness of 15-150 μm, a low areal density and an open structure; and
a biocompatible and biostable polyurethane elastomer comprising polysiloxane segments, the polyurethane elastomer forming a continuous matrix of the composite sheet which fully covers and embeds the strands of the fabric sufficient to render the composite sheet non-porous; wherein
the composite sheet comprises 10-90 mass % of the polyurethane elastomer, has a thickness of 25-250 μm and an areal density of 5-300 g/m2; and wherein
the composite sheet has, in at least one direction, a non-linear uniaxial tensile behavior characterized by a 1%-secant modulus of 20-200 MPa, a hardening transition point at 10-45%, and a tensile strength of at least 25 MPa as measured in water at 37° C.