US 12,440,602 B2
Biocompatible compositions comprising a biocompatible thickening polymer and a chitosan derivative
Andrea Travan, Trieste (IT); Massimiliano Antonio Borgogna, Monfalcone (IT); Matteo Parravicini, Como (IT); Angelo De Lollis, Como (IT); and Francesco Siccardi, Morcote (CH)
Assigned to Medacta International SA, Caster San Pietro (CH)
Appl. No. 17/597,280
Filed by Medacta International SA, Castel San Pietro (CH)
PCT Filed Jul. 2, 2020, PCT No. PCT/EP2020/068733
§ 371(c)(1), (2) Date Dec. 30, 2021,
PCT Pub. No. WO2021/001507, PCT Pub. Date Jan. 7, 2021.
Claims priority of application No. 102019000010740 (IT), filed on Jul. 2, 2019.
Prior Publication US 2022/0313868 A1, Oct. 6, 2022
Int. Cl. A61L 27/34 (2006.01); A61L 27/54 (2006.01); C08L 1/28 (2006.01); C08L 5/08 (2006.01)
CPC A61L 27/34 (2013.01) [A61L 27/54 (2013.01); C08L 1/284 (2013.01); C08L 5/08 (2013.01); A61L 2300/104 (2013.01); A61L 2300/404 (2013.01); A61L 2430/24 (2013.01)] 19 Claims
 
1. A biocompatible composition in powder form suitable for preparing a biocompatible composition in gel form, the composition in powder form comprising a biocompatible thickening polymer as a gelling agent and a chitosan derivative comprising D-glucosamine units of the following formula (I):

OG Complex Work Unit Chemistry
wherein X is an alditolic or aldonic polyol residue of an oligosaccharide,
wherein said oligosaccharide is lactose,
wherein said biocompatible thickening polymer is a non-ionic cellulosic polysaccharide selected from the group consisting of hydroxypropyl methyl cellulose (HPMC), methyl cellulose (MC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC) and ethyl methyl cellulose (EMC), or mixtures thereof, and
wherein said chitosan derivative synergistically interacts with said biocompatible thickening polymer to provide enhanced adhesion on a surface.