	US 12,440,600 B2
	Biocompatible, flexible, haemostatic sheet
Abraham Reinier Keereweer, Nijmegen (NL); Rosa Pilar Félix Lanao, Nijmegen (NL); Joost Opsteen, Nijmegen (NL); and Johannes Caspar Mathias Elizabeth Bender, Nijmegen (NL)
Assigned to CILAG GMBH INTERNATIONAL, Zug (CH)
Filed by GATT TECHNOLOGIES B.V., Nijmegen (NL)
Filed on Jan. 11, 2022, as Appl. No. 17/573,537.
Application 17/573,537 is a continuation of application No. PCT/EP2020/069441, filed on Jul. 9, 2020.
Claims priority of application No. 19186036 (EP), filed on Jul. 12, 2019; and application No. 20151779 (EP), filed on Jan. 14, 2020.
Prior Publication US 2022/0133947 A1, May 5, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 24/00 (2006.01); A61L 15/64 (2006.01); C08L 79/02 (2006.01)

CPC A61L 24/0073 (2013.01) [A61L 24/0042 (2013.01); C08L 79/02 (2013.01); A61L 15/64 (2013.01); A61L 2400/04 (2013.01); C08L 2205/22 (2013.01); C08L 2312/00 (2013.01)]

29 Claims

1. A biocompatible, flexible, haemostatic sheet comprising:

(a) a water-resistant cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space and fibres comprising a nucleophilic polymer carrying reactive nucleophilic groups; and

(b) distributed within the interstitial space throughout the fibrous carrier structure, a plurality of reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least three reactive electrophilic groups that are capable of reacting with both amine groups in tissue and blood and with the reactive nucleophilic groups of the nucleophilic polymer to form covalent bonds,

wherein the reactive polymer particles have a diameter between 0.5-100 μm and are present in an amount of at least 3% by weight of the fibrous carrier structure.