US 12,440,599 B2
Water activated hydrogel-based medical patches, and methods of making and using such patches
Michael Bassett, Hampton, NH (US); and David Giusti, North Reading, MA (US)
Assigned to PRAMAND LLC, Bedford, MA (US)
Filed by Pramand LLC, Bedford, MA (US)
Filed on May 6, 2022, as Appl. No. 17/738,847.
Prior Publication US 2023/0355829 A1, Nov. 9, 2023
Int. Cl. A61L 24/00 (2006.01); A61K 9/70 (2006.01); A61L 24/04 (2006.01)
CPC A61L 24/0031 (2013.01) [A61K 9/70 (2013.01); A61L 24/0015 (2013.01); A61L 24/0036 (2013.01); A61L 24/043 (2013.01); A61L 2400/04 (2013.01); A61L 2430/36 (2013.01)] 39 Claims
 
1. A medical patch comprising a biocompatible substrate and a dry hydrogel precursor layer on the substrate, the dry hydrogel precursor layer comprising an electrophilic-hydrogel precursor having a plurality of electrophilic functional groups and a nucleophilic-hydrogel precursor having a plurality of protonated amine groups and no more than about 2 weight percent water and wherein both the electrophilic-hydrogel precursor and the nucleophilic-hydrogel precursor are substantially uncrosslinked, and are blended or in direct contact with each other.