US 12,440,598 B2
Medical molded article, medical device, and nerve guidance conduit
Kenichi Harimoto, Otsu (JP); and Hirokazu Sakaguchi, Otsu (JP)
Assigned to Toray Industries, Inc., Tokyo (JP)
Appl. No. 17/292,809
Filed by Toray Industries, Inc., Tokyo (JP)
PCT Filed Dec. 11, 2019, PCT No. PCT/JP2019/048392
§ 371(c)(1), (2) Date May 11, 2021,
PCT Pub. No. WO2020/122096, PCT Pub. Date Jun. 18, 2020.
Claims priority of application No. 2018-233153 (JP), filed on Dec. 13, 2018.
Prior Publication US 2021/0393847 A1, Dec. 23, 2021
Int. Cl. A61L 17/12 (2006.01); A61L 27/18 (2006.01); A61L 27/58 (2006.01); A61L 31/06 (2006.01); A61L 31/14 (2006.01)
CPC A61L 17/12 (2013.01) [A61L 27/18 (2013.01); A61L 27/58 (2013.01); A61L 31/06 (2013.01); A61L 31/148 (2013.01); A61L 2430/22 (2013.01); A61L 2430/32 (2013.01)] 10 Claims
 
1. A medical molded article comprising a bioabsorbable polyester,
the medical molded article having an amount-of-work-holding rate of 55% or more,
the amount-of-work-holding rate defined as a rate of an amount of work generated finally by an operation that is repeated 10 times to an amount of work generated first by the operation,
the operation in which a tensile stress is applied to the medical molded article in a direction of a maximum length of the medical molded article to generate a tensile strain of 100% with respect to an initial length;
wherein the bioabsorbable polyester comprises a polyester copolymer including a hydroxycarboxylic acid residue and a lactone residue as main structural units;
wherein the hydroxycarboxylic acid residue comprises a lactic acid residue, and the lactone residue comprises a caprolactone residue;
wherein the polyester copolymer comprises a multimerized macromer;
wherein the multimerized macromer has a gradient structure; and
wherein the multimerized macromer has a structure in which a plurality of molecular chains are repeated that have a gradient structure having a composition gradient of the hydroxycarboxylic acid residue and the lactone residue in the molecular chains.