US 12,440,587 B2
Particles functionalized with imageable radioisotopes and methods of making and use thereof
James Radford Stone, Charlottesville, VA (US); Kiel Douglas Neumann, Charlottesville, VA (US); and Matthew Robert Dreher, Dover, MA (US)
Assigned to Boston Scientific Medical Device Limited, Galway (IE); and University of Virginia Patent Foundation, Charlottesville, VA (US)
Filed by Boston Scientific Medical Device Limited, Galway (IE); and University of Virginia Patent Foundation, Charlottesville, VA (US)
Filed on Jan. 8, 2024, as Appl. No. 18/407,111.
Application 18/407,111 is a division of application No. 17/166,820, filed on Feb. 3, 2021, granted, now 11,904,029.
Claims priority of provisional application 62/970,587, filed on Feb. 5, 2020.
Prior Publication US 2024/0139354 A1, May 2, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 51/12 (2006.01); A61B 6/03 (2006.01); A61K 51/02 (2006.01); A61N 5/10 (2006.01)
CPC A61K 51/1244 (2013.01) [A61B 6/037 (2013.01); A61K 51/02 (2013.01); A61N 5/1001 (2013.01); A61N 2005/1021 (2013.01); A61N 2005/1052 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for determining an amount of therapeutic microspheres to provide to a body of a patient, the method comprising:
delivering a population of imageable microspheres to the patient by introducing the population of imageable microspheres to a first position in a vasculature of the patient;
allowing the population of imageable microspheres to distribute within the body of the patient;
determining a distribution of at least a portion of the population of the imageable microspheres within the body of the patient by imaging a portion of the body of the patient using an imaging modality; and
using the distribution of the imageable microspheres to calculate an amount of therapeutic microspheres to be delivered to the body of the patient;
the imageable microspheres comprising a substrate and at least one imageable radioisotope bound to a surface of the substrate;
wherein the substrate comprises silicon dioxide and at least one other element selected from manganese, aluminum, gallium, yttrium, boron, strontium, and titanium;
wherein the at least one imageable radioisotope is selected from 99mTc, 201Th, 51Cr, 67Ga, 68Ga, 111In, 64Cu, 89Zr, 59Fe, 42K, 82Rb, 24Na, 45Ti, 44Sc, 51Cr, 177Lu, 18F, and/or combinations thereof; and
wherein the at least one imageable radioisotope is bound directly to the surface of the substrate through non-metal atoms of the substrate and/or wherein the at least one imageable radioisotope is bound to the surface of the substrate through an inorganic bridge comprising the non-metal atoms of the substrate.