US 12,440,585 B2
Zwitterionic metal chelators
John V. Frangioni, Weston, MA (US); and Wolfgang Maison, Winsen (DE)
Assigned to Curadel Surgical Innovations, Inc., Natick, MA (US)
Filed by Curadel Surgical Innovations, Inc., Natick, MA (US)
Filed on Apr. 19, 2024, as Appl. No. 18/640,169.
Claims priority of provisional application 63/538,038, filed on Sep. 12, 2023.
Prior Publication US 2025/0082792 A1, Mar. 13, 2025
Int. Cl. A61K 51/04 (2006.01); A61B 6/03 (2006.01); A61K 49/00 (2006.01); A61K 51/08 (2006.01)
CPC A61K 51/0482 (2013.01) [A61B 6/037 (2013.01); A61K 49/0032 (2013.01); A61K 51/0478 (2013.01); A61K 51/082 (2013.01); A61K 2121/00 (2013.01); A61K 2123/00 (2013.01)] 9 Claims
 
1. A zwitterionic metal chelator complex comprising a metal chelator having zwitterionic groups and a metal or metal isotope selected from the group consisting of a radionuclide, a label, a paramagnetic metal and a heavy metal,
wherein the metal chelator is a derivative of DOTA having the formula:

OG Complex Work Unit Chemistry
wherein ZWI is an N-oxide zwitterionic group; and each instance of W and Y independently is a linking group.