US 12,440,577 B2
Sol-gel vaults and methods of making and using thereof
Leonard H. Rome, Tarzana, CA (US); Shaily Mahendra, Santa Monica, CA (US); Meng Wang, Los Angeles, CA (US); Valerie Ann Kickhoefer, Sherman Oaks, CA (US); Esther Hui-Jen Lan, Rancho Palos Verdes, CA (US); and Bruce S. Dunn, Los Angeles, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/427,729
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Feb. 22, 2020, PCT No. PCT/US2020/019378
§ 371(c)(1), (2) Date Aug. 2, 2021,
PCT Pub. No. WO2020/176363, PCT Pub. Date Sep. 3, 2020.
Claims priority of provisional application 62/809,848, filed on Feb. 25, 2019.
Prior Publication US 2022/0105199 A1, Apr. 7, 2022
Int. Cl. A61K 47/69 (2017.01); A61K 9/06 (2006.01); A61K 38/43 (2006.01); A61K 47/24 (2006.01)
CPC A61K 47/6903 (2017.08) [A61K 9/06 (2013.01); A61K 38/43 (2013.01); A61K 47/24 (2013.01); A61K 47/6927 (2017.08)] 4 Claims
OG exemplary drawing
 
1. A method of counteracting, degrading, or inactivating a bisphenol in a material, which comprises
making sol-gel vaults by precipitating silica sol-gel particles on vault particles having manganese peroxidase packaged within their interior cavities by contacting the vault particles with a mixture of pre-hydrolyzed tetramethyl orthosilicate having a pH of 5.5 to 6.5 for about 30 minutes or more; and
contacting the material with the sol-gel vaults.