US 12,440,537 B1
Compositions and methods for treating skin diseases, disorders, or conditions
Cristina de Guzman Strong, St. Louis, MO (US); and Erin Brettmann, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Cristina de Guzman Strong, St. Louis, MO (US); and Erin Brettmann, St. Louis, MO (US)
Filed on Oct. 13, 2021, as Appl. No. 17/500,452.
Claims priority of provisional application 63/090,801, filed on Oct. 13, 2020.
Int. Cl. A61K 38/17 (2006.01); A61K 31/593 (2006.01); A61P 17/00 (2006.01)
CPC A61K 38/1709 (2013.01) [A61K 31/593 (2013.01); A61P 17/00 (2018.01)] 19 Claims
 
1. A method of increasing skin barrier or epidermis integrity to a subject in need thereof, the method comprising: topically administering to the subject a therapeutically effective amount of an involucrin (IVL) late region repeat peptide selected from the group consisting of SEQ ID NO: 1 (ELPEQQEGQL) and a fragment of SEQ ID NO: 1, wherein the fragment of SEQ ID NO: 1 is selected from the group consisting of:
 
 (SEQ ID NO: 71)
 
 ELPEQQ;
 
 
 
 (SEQ ID NO: 72)
 
 LPEQQE;
 
 
 
 (SEQ ID NO: 73)
 
 PEQQEG;
 
 
 
 (SEQ ID NO: 6)
 
 EQQEGQ;
 
 
 
 (SEQ ID NO: 74)
 
 QQEGQL;
 
 
 
 (SEQ ID NO: 75)
 
 ELPEQQE;
 
 
 
 (SEQ ID NO: 76)
 
 LPEQQEG;
 
 
 
 (SEQ ID NO: 77)
 
 PEQQEGQ;
 
 
 
 (SEQ ID NO: 78)
 
 EQQEGQL;
 
 
 
 (SEQ ID NO: 79)
 
 ELPEQQEG;
 
 
 
 (SEQ ID NO: 80)
 
 LPEQQEGQ;
 
 
 
 (SEQ ID NO: 81)
 
 PEQQEGQL;
 
 
 
 (SEQ ID NO: 82)
 
 ELPEQQEGQ; and
 
 
 
 (SEQ ID NO: 83)
 
 LPEQQEGQL.