US 12,440,525 B2
Compositions and methods for enhancing production, growth, spread, or oncolytic and immunotherapeutic efficacy of interferon-sensitive viruses
Jean-Simon Diallo, Ottawa (CA); Mohammed Selman, Ann Arbor, MI (US); Rozanne Arulanandam, Orleans (CA); Nicole Elise Forbes, Ottawa (CA); and Ramya Krishnan, Ottawa (CA)
Assigned to OTTAWA HOSPITAL RESEARCH INSTITUTE, Ottawa (CA)
Filed by Ottawa Hospital Research Institute, Ottawa (CA)
Filed on May 31, 2024, as Appl. No. 18/680,187.
Application 18/680,187 is a continuation of application No. 16/763,013, granted, now 12,076,353, previously published as PCT/CA2018/051492, filed on Nov. 23, 2018.
Claims priority of provisional application 62/590,456, filed on Nov. 24, 2017.
Prior Publication US 2024/0307469 A1, Sep. 19, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 7/00 (2006.01); A61K 31/225 (2006.01); A61K 35/766 (2015.01); A61P 35/00 (2006.01); C07C 69/60 (2006.01); A61K 39/00 (2006.01)
CPC A61K 35/766 (2013.01) [A61K 31/225 (2013.01); A61P 35/00 (2018.01); C07C 69/60 (2013.01); C12N 7/00 (2013.01); A61K 2039/585 (2013.01); C12N 2710/10332 (2013.01); C12N 2710/10351 (2013.01); C12N 2740/16134 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/20232 (2013.01); C12N 2760/20251 (2013.01)] 20 Claims
 
1. A method for increasing the capacity of an interferon-sensitive virus to infect, transduce, grow or replicate in a cell or spread within one or more tissues, the method comprising:
administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof,

OG Complex Work Unit Chemistry
wherein R1 and R2 are each independently OH, (C1-2)alkoxy or linear, branched or cyclic, saturated or unsaturated (C3-20)alkoxy; said alkoxy is optionally substituted with one or more halogen, OH, (C1-4) alkyl, nitro or cyano;
wherein when one of R1 and R2 is OH, the other of R1 and R2 is not OH,
to the cell before, concurrently with, or after infection of the cell with the interferon-sensitive virus.