US 12,440,523 B2
Immunomodulatory compositions comprising microbial entities
Eric Michael Schott, West Roxbury, MA (US); Gerardo V. Toledo, Hopkinton, MA (US); Maria Juliana Soto-Giron, Cambridge, MA (US); Alicia Eve Ballok, Natick, MA (US); Ryan Green, Somerville, MA (US); and Mark Charbonneau, Medford, MA (US)
Assigned to Solarea Bio, Inc., Waltham, MA (US)
Filed by Solarea Bio, Inc., Cambridge, MA (US)
Filed on Sep. 28, 2023, as Appl. No. 18/477,298.
Application 18/477,298 is a continuation of application No. 18/304,264, filed on Apr. 20, 2023, granted, now 12,016,891.
Application 18/304,264 is a continuation of application No. PCT/US2022/053684, filed on Dec. 21, 2022.
Claims priority of provisional application 63/348,854, filed on Jun. 3, 2022.
Claims priority of provisional application 63/292,362, filed on Dec. 21, 2021.
Prior Publication US 2024/0131091 A1, Apr. 25, 2024
Prior Publication US 2024/0226201 A9, Jul. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/747 (2015.01); A23L 33/105 (2016.01); A23L 33/135 (2016.01); A23L 33/15 (2016.01); A61K 31/525 (2006.01); A61K 35/742 (2015.01); A61K 45/06 (2006.01); A61P 29/00 (2006.01)
CPC A61K 35/747 (2013.01) [A23L 33/105 (2016.08); A23L 33/135 (2016.08); A23L 33/15 (2016.08); A61K 31/525 (2013.01); A61K 35/742 (2013.01); A61K 45/06 (2013.01); A61P 29/00 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A pharmaceutical composition comprising
a) a combination of four heterologous microbes comprising:
Lactobacillus harbinensis, Lactobacillus brevis, Lactococcus lactis, and Bacillus velezensis, wherein the heterologous microbes are formulated as a synthetic microbial consortium comprising about 1.0×108 to about 1.0×1012 CFU of each of the heterologous microbes, wherein at least one of the heterologous microbes comprises a 16S rRNA sequence having at least 97% identity to any one of SEQ ID NOs: 43, 198, 221, and 224, formulated in an amount effective to produce an anti-inflammatory effect in a human subject; and
b) a pharmaceutically acceptable excipient.