US 12,440,522 B2
Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause
Eric Michael Schott, West Roxbury, MA (US); Maria Juliana Soto-Giron, Cambridge, MA (US); and Gerardo V. Toledo, Hopkinton, MA (US)
Assigned to Solarea Bio, Inc., Cambridge, MA (US)
Filed by Solarea Bio, Inc., Cambridge, MA (US)
Filed on Dec. 26, 2023, as Appl. No. 18/395,925.
Application 18/395,925 is a continuation of application No. 18/181,495, filed on Mar. 9, 2023, granted, now 11,938,158.
Application 18/181,495 is a continuation of application No. PCT/US2022/080362, filed on Nov. 22, 2022.
Claims priority of provisional application 63/382,666, filed on Nov. 7, 2022.
Claims priority of provisional application 63/282,155, filed on Nov. 22, 2021.
Prior Publication US 2024/0123001 A1, Apr. 18, 2024
Int. Cl. A61K 35/66 (2015.01); A61K 9/00 (2006.01); A61K 31/122 (2006.01); A61K 31/355 (2006.01); A61K 31/375 (2006.01); A61K 31/593 (2006.01); A61K 35/744 (2015.01); A61K 35/747 (2015.01); A61K 36/064 (2006.01); A61K 47/26 (2006.01); A61K 47/46 (2006.01); A61P 15/12 (2006.01)
CPC A61K 35/747 (2013.01) [A61K 9/0056 (2013.01); A61K 31/122 (2013.01); A61K 31/355 (2013.01); A61K 31/375 (2013.01); A61K 31/593 (2013.01); A61K 35/744 (2013.01); A61K 36/064 (2013.01); A61K 47/26 (2013.01); A61K 47/46 (2013.01); A61P 15/12 (2018.01)] 16 Claims
OG exemplary drawing
 
1. A method of lessening a decrease in, maintaining, or improving bone health in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising each of four heterologous microbes consisting of Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii.