US 12,440,521 B2
Materials and methods for improving immune responses and skin and/or mucosal barrier functions
Eva A. Berkes, Sarasota, FL (US); Nicholas T. Monsul, Sarasota, FL (US); and Frederick T. Boehm, Sarasota, FL (US)
Assigned to QUORUM INNOVATIONS, INC., Sarasota, FL (US)
Filed by Quorum Innovations, Inc., Sarasota, FL (US)
Filed on Jan. 28, 2023, as Appl. No. 18/161,046.
Application 18/161,046 is a continuation of application No. 16/806,000, filed on Mar. 2, 2020, granted, now 11,564,957.
Application 16/806,000 is a continuation of application No. 15/629,439, filed on Jun. 21, 2017, granted, now 10,617,726, issued on Apr. 4, 2020.
Application 15/629,439 is a continuation of application No. 15/496,686, filed on Apr. 25, 2017, granted, now 10,004,772, issued on Jun. 26, 2018.
Application 15/496,686 is a continuation of application No. 15/226,226, filed on Aug. 2, 2016, granted, now 9,706,778, issued on Jul. 18, 2017.
Application 15/226,226 is a continuation of application No. PCT/US2016/042939, filed on Jul. 19, 2016.
Claims priority of provisional application 62/194,630, filed on Jul. 20, 2015.
Prior Publication US 2023/0165915 A1, Jun. 1, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/747 (2015.01); A01N 63/20 (2020.01); A23L 33/135 (2016.01); A61K 35/74 (2015.01); C12N 1/20 (2006.01); C12R 1/225 (2006.01)
CPC A61K 35/747 (2013.01) [A01N 63/20 (2020.01); A23L 33/135 (2016.08); A61K 35/74 (2013.01); C12N 1/205 (2021.05); A23V 2002/00 (2013.01); A23V 2400/143 (2023.08); C12R 2001/225 (2021.05)] 12 Claims
OG exemplary drawing
 
1. A composition comprising an isolated Lactobacillus fermentum bacterial strain grown as biofilm, and/or comprising a bioactive extract of said biofilm, wherein the biological activity of the bioactive extract, is selected from antimicrobial activity, promoting commensal bacterial growth, enhancing skin or mucous membrane barrier function and enhancing a skin innate immune function, wherein the bacterial strain is Lactobacillus fermentum Qi6 having Accession No. PTA-122195.