US 12,440,520 B2
Soft capsule containing tyndalized bacteria in film
Seung Woo Yang, Seoul (KR); Jin Kyo Lee, Gyeonggi-do (KR); Hyung Soo Shin, Gyeonggi-do (KR); Dong Hyun Yoo, Seoul (KR); Jung A Kim, Incheon (KR); and Eun Bora Kim, Busan (KR)
Assigned to PHIL INTERNATIONAL CO., LTD., Seoul (KR)
Appl. No. 17/636,158
Filed by PHIL INTERNATIONAL CO., LTD., Seoul (KR)
PCT Filed May 4, 2020, PCT No. PCT/KR2020/005920
§ 371(c)(1), (2) Date Feb. 17, 2022,
PCT Pub. No. WO2021/033871, PCT Pub. Date Feb. 25, 2021.
Claims priority of application No. 10-2019-0101684 (KR), filed on Aug. 20, 2019; and application No. 10-2020-0048844 (KR), filed on Apr. 22, 2020.
Prior Publication US 2022/0288139 A1, Sep. 15, 2022
Int. Cl. A61K 35/747 (2015.01); A61K 9/48 (2006.01); A61K 35/744 (2015.01); A61K 35/745 (2015.01)
CPC A61K 35/747 (2013.01) [A61K 9/4825 (2013.01); A61K 9/4875 (2013.01); A61K 35/744 (2013.01); A61K 35/745 (2013.01)] 10 Claims
 
1. A soft capsule which includes:
a core of the soft capsule containing a fill solution; and
a capsule shell layer surrounding the core of the soft capsule and comprising dead bacteria;
wherein the capsule shell layer comprises the dead bacteria which are homogeneously dispersed throughout the entire area of the capsule shell; and
wherein the capsule shell layer comprises 0.001 to 100 mg of the dead bacteria per 1 g of the capsule shell layer.