US 12,440,518 B2
Bacillus strains for improving feed conversion rates and body weight gain in animals
Adam Nelson, Salem, VA (US); Erik Eckhardt, Domerat (FR); Estelle Devillard, Antony (FR); Meagan Hale, Roanoke, VA (US); Emily Zhang, Durham, NC (US); and Ethan Chad Baker, Roanoke, VA (US)
Assigned to NOVOZYMES A/S, Bagsvaerd (DK)
Filed by NOVOZYMES A/S, Bagsvaerd (DK)
Filed on Nov. 12, 2024, as Appl. No. 18/944,516.
Application 17/933,582 is a division of application No. 16/965,866, granted, now 11,478,514, issued on Oct. 25, 2022, previously published as PCT/US2019/016271, filed on Feb. 1, 2019.
Application 18/944,516 is a continuation of application No. 18/485,268, filed on Oct. 11, 2023, granted, now 12,171,792.
Application 18/485,268 is a continuation of application No. 17/933,582, filed on Sep. 20, 2022, granted, now 11,819,525, issued on Nov. 21, 2023.
Claims priority of provisional application 62/625,549, filed on Feb. 2, 2018.
Prior Publication US 2025/0064870 A1, Feb. 27, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/02 (2006.01); A23K 10/18 (2016.01); A23K 50/30 (2016.01); A61K 35/742 (2015.01); C12N 1/20 (2006.01); C12R 1/10 (2006.01); C12R 1/125 (2006.01)
CPC A61K 35/742 (2013.01) [A23K 10/18 (2016.05); A23K 50/30 (2016.05); C12N 1/205 (2021.05); C12R 2001/10 (2021.05); C12R 2001/125 (2021.05)] 20 Claims
 
1. A method comprising administering to an animal an amount of one or more Bacillus strains selected from the group consisting of:
a) Bacillus licheniformis strain O42AH3 having deposit accession number DSM 32559 and strains having all the identifying characteristics thereof;
b) Bacillus subtilis strain 052YJ6 having deposit accession number DSM 32560 and strains having all the identifying characteristics thereof;
c) Bacillus amyloliquefaciens strain 052YYT having deposit accession number DSM 32561 and strains having all the identifying characteristics thereof; and
d) Bacillus pumilus strain O72NR7 having deposit accession number DSM 32563 and strains having all the identifying characteristics thereof, and said amount effective to:
i. improve one or more performance parameters of said animal;
ii. prevent a Lawsonia intracellularis infection of said animal; and/or
iii. alleviate a Lawsonia intracellularis infection in said animal.