US 12,440,507 B2
Sting inhibitors and their therapeutic uses
Nadine Laguette, Clapiers (FR); Jessica Guerra, Montpellier (FR); Barbara Nawrot, Dabrowka Wielka (PL); and Renata Kaczmarek, Lodz (PL)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); UNIVERSITÉ DE MONTPELIER, Montpelier (FR); and CENTER OF MOLECULAR AND MACROMOLECULAR STUDIES, Lodz (PL)
Appl. No. 17/638,537
Filed by CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); Université de Montpellier, Montpellier (FR); and Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Lodz (PL)
PCT Filed Sep. 4, 2020, PCT No. PCT/EP2020/074785
§ 371(c)(1), (2) Date Feb. 25, 2022,
PCT Pub. No. WO2021/043992, PCT Pub. Date Mar. 11, 2021.
Claims priority of application No. 19306072 (EP), filed on Sep. 6, 2019.
Prior Publication US 2023/0017490 A1, Jan. 19, 2023
Int. Cl. A61K 31/7076 (2006.01); A61P 29/00 (2006.01)
CPC A61K 31/7076 (2013.01) [A61P 29/00 (2018.01)] 16 Claims
 
1. A method for inhibiting inflammation in a subject in need thereof, comprising administering to said subject a compound chosen from compounds of formula (I), their diastereoisomers and their salts:

OG Complex Work Unit Chemistry
wherein:
X is an oxygen or sulfur atom,
Y is an oxygen or sulfur atom or —NH—,
Ado is the adenosine residue,
R1 is selected from the groups consisting of

OG Complex Work Unit Chemistry
wherein Z is —OH, —OP(S)(OAdo)(OH), N3, NH2, —CH3 or

OG Complex Work Unit Chemistry
wherein R2 and R3 each represents a C1-C6 alkyl group or an aryl group,

OG Complex Work Unit Chemistry
wherein Z represents —OH or —OP(O)(OH)2,

OG Complex Work Unit Chemistry
wherein Z represents —OH, —OP(O)(OH)2 or —OP(O)(OH)(OAdo),

OG Complex Work Unit Chemistry
wherein Z represents a covalent bond, H, —OH or a C1-C6 alkyl group, and

OG Complex Work Unit Chemistry
wherein Z represents a covalent bond, H, —OH or a C1-C5 alkyl group.