US 12,440,505 B2
Method of treating cancer
Hiroeki Sahara, Sagamihara (JP); Tomohiro Nakayama, Tokyo (JP); and Takuya Maruo, Sagamihara (JP)
Assigned to M.T.3, INC., Tokyo (JP); NIHON UNIVERSITY, Tokyo (JP); and SCHOOL CORPORATION, AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION, Sagamihara (JP)
Filed by M.T.3, Inc., Tokyo (JP); NIHON UNIVERSITY, Tokyo (JP); and SCHOOL CORPORATION, AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION, Sagamihara (JP)
Filed on Sep. 3, 2021, as Appl. No. 17/465,921.
Application 17/465,921 is a continuation of application No. PCT/JP2019/041730, filed on Oct. 24, 2019.
Claims priority of application No. 2019-039749 (JP), filed on Mar. 5, 2019.
Prior Publication US 2021/0393660 A1, Dec. 23, 2021
Int. Cl. A61K 31/7032 (2006.01); A61N 5/10 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/7032 (2013.01) [A61N 5/10 (2013.01); A61P 35/00 (2018.01); A61N 2005/1098 (2013.01)] 9 Claims
 
1. A method of treating cancer comprising repeating a set of administration of a compound represented by General Formula (I) or a pharmaceutically acceptable salt thereof to a patient, at a dosage such that 8 mg/kg or less of the compound represented by General Formula (I) is administered per dose, and irradiation to the patient immediately following the administration:

OG Complex Work Unit Chemistry
where R1 is an acyl residue from fatty acid,
wherein a total dosage of the irradiation on a cancer is 10 Gy or more, and
wherein the patient is a dog or cat.