US 12,440,482 B2
1,4-dihydropyridine compositions, methods of making and use
Daniel Walter Wehrung, Johnstown, OH (US); Meng Zhong, Westerville, OH (US); Saral Pinkal Patel, Powell, OH (US); and Bindhu Madhavi Rayaprolu, Columbus, OH (US)
Assigned to American Regent, Inc., Shirley, NY (US)
Filed by American Regent, Inc., Shirley, NY (US)
Filed on Oct. 1, 2021, as Appl. No. 17/491,836.
Application 17/491,836 is a continuation of application No. 16/815,776, filed on Mar. 11, 2020, granted, now 11,135,208.
Claims priority of provisional application 62/885,704, filed on Aug. 12, 2019.
Prior Publication US 2022/0016097 A1, Jan. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4422 (2006.01); A61K 47/18 (2017.01)
CPC A61K 31/4422 (2013.01) [A61K 47/183 (2013.01)] 27 Claims
 
1. A sterile composition comprising nicardipine and a chelating agent, the chelating agent in an amount of 0.001 weight percent to 10 weight percent of the composition, wherein the composition is in a container and the chelating agent is ethylenediaminetetraacetic acid (EDTA), ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA), diethylenetriaminepentaacetic acid (DTPA), deferoxamine mesylate or free bases, hydrates, solvates, crystalline polymorphs, amorphous forms or pharmaceutically acceptable salts thereof.