US 12,440,479 B2
Prevention or treatment of chronic organ injury
Michael Zeisberg, Goettingen (DE); Elisabeth Zeisberg, Goettingen (DE); Björn Tampe, Goettingen (DE); Désiree Tampe, Goettingen (DE); Gerhard Anton Mueller, Tuebingen (DE); and Raghu Kalluri, Houston, TX (US)
Assigned to GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLICHEN RECHTS, UNIVERSITAETSMEDIZIN, Goettingen (DE); and BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Appl. No. 17/042,027
Filed by GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLICHEN RECHTS, UNIVERSITAETSMEDIZIN, Goettingen (DE); and BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
PCT Filed Mar. 27, 2019, PCT No. PCT/EP2019/057712
§ 371(c)(1), (2) Date Sep. 25, 2020,
PCT Pub. No. WO2019/185708, PCT Pub. Date Oct. 3, 2019.
Claims priority of provisional application 62/649,245, filed on Mar. 28, 2018.
Prior Publication US 2021/0008044 A1, Jan. 14, 2021
Int. Cl. A61K 31/35 (2006.01); A61K 31/436 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61P 1/16 (2006.01); A61P 9/00 (2006.01); A61P 13/12 (2006.01); C12N 15/113 (2010.01)
CPC A61K 31/436 (2013.01) [A61K 31/35 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61P 1/16 (2018.01); A61P 9/00 (2018.01); A61P 13/12 (2018.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3233 (2013.01)] 24 Claims
 
1. A method for the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of an organ of a subject in need thereof, comprising the step of administering an agent to said subject to increase homodimer-formation of ARNT in said organ.