US 12,440,458 B2
Epinephrine formulations
Suketu Sanghvi, Kendall Park, NJ (US); Vinayagam Kannan, Morris Plains, NJ (US); and Matthew Kenney, New Haven, MI (US)
Assigned to PH HEALTH LIMITED, Ballsbridge (IE)
Filed by PAR PHARMACEUTICAL, INC., Chestnut Ridge, NY (US)
Filed on Mar. 2, 2022, as Appl. No. 17/685,090.
Application 17/685,090 is a continuation of application No. 16/817,253, filed on Mar. 12, 2020, granted, now 11,337,938.
Application 16/817,253 is a continuation of application No. 16/258,204, filed on Jan. 25, 2019, granted, now 10,624,864, issued on Apr. 21, 2020.
Application 16/258,204 is a continuation of application No. 15/969,500, filed on May 2, 2018, abandoned.
Application 15/969,500 is a continuation of application No. 15/455,991, filed on Mar. 10, 2017, abandoned.
Application 15/455,991 is a continuation in part of application No. 14/863,112, filed on Sep. 23, 2015, granted, now 10,130,592, issued on Nov. 20, 2018.
Application 14/863,112 is a continuation of application No. 14/818,121, filed on Aug. 4, 2015, granted, now 9,295,657, issued on Mar. 29, 2016.
Application 14/818,121 is a continuation of application No. 14/657,990, filed on Mar. 13, 2015, granted, now 9,119,876, issued on Sep. 1, 2015.
Prior Publication US 2023/0100523 A1, Mar. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/137 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 47/12 (2006.01); A61K 47/20 (2006.01)
CPC A61K 31/137 (2013.01) [A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 47/12 (2013.01); A61K 47/20 (2013.01); A61K 9/0014 (2013.01); A61K 9/0048 (2013.01); A61K 9/0073 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A pre-filled syringe containing a composition, the composition comprising:
epinephrine and/or salts thereof,
a tonicity regulating agent,
a pH raising agent,
an antioxidant comprising glutathione,
a pH lowering agent,
a transition metal complexing agent, and
water.