	US 12,440,450 B2
	Fibrin particles and methods of making the same
Ismaeel Muhamed, Raleigh, NC (US); Ashley C. Brown, Raleigh, NC (US); and Frances S. Ligler, Raleigh, NC (US)
Assigned to North Carolina State University, Raleigh, NC (US)
Filed by NORTH CAROLINA STATE UNIVERSITY, Raleigh, NC (US)
Filed on Sep. 7, 2023, as Appl. No. 18/462,701.
Application 18/462,701 is a division of application No. 16/768,760, granted, now 11,786,477, previously published as PCT/US2018/063619, filed on Dec. 3, 2018.
Claims priority of provisional application 62/593,556, filed on Dec. 1, 2017.
Prior Publication US 2023/0414527 A1, Dec. 28, 2023
Int. Cl. A61K 9/14 (2006.01); A61K 9/50 (2006.01); A61K 45/06 (2006.01); A61K 47/69 (2017.01); A61P 17/02 (2006.01)

CPC A61K 9/5052 (2013.01) [A61K 9/5089 (2013.01); A61K 45/06 (2013.01); A61K 47/6925 (2017.08); A61P 17/02 (2018.01)]

20 Claims

1. A method of preparing a fibrin particle, comprising shearing an aqueous composition comprising fibrin into particles having a crosslinking density no greater than 15%, wherein the shearing does not denature the fibrin.