US 12,440,446 B2
Polymeric delivery systems
Jeremy J. Harris, Doylestown, PA (US); Scott Radzinski, Gilbertsville, PA (US); Brian Ginn, Harleysville, PA (US); Peter D. Gabriele, Frisco, TX (US); and Benjamin Roadarmel, Quakertown, PA (US)
Assigned to THE SECANT GROUP, LLC, Telford, PA (US)
Filed by THE SECANT GROUP, LLC, Telford, PA (US)
Filed on Oct. 25, 2022, as Appl. No. 18/049,519.
Claims priority of provisional application 63/271,283, filed on Oct. 25, 2021.
Claims priority of provisional application 63/271,275, filed on Oct. 25, 2021.
Prior Publication US 2023/0125499 A1, Apr. 27, 2023
Int. Cl. A61K 9/51 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 47/34 (2017.01); B82Y 5/00 (2011.01); C08F 120/60 (2006.01); A61K 48/00 (2006.01)
CPC A61K 9/1647 (2013.01) [A61K 9/5026 (2013.01); A61K 9/5146 (2013.01); A61K 31/7105 (2013.01); A61K 31/711 (2013.01); A61K 47/34 (2013.01); B82Y 5/00 (2013.01); C08F 120/60 (2013.01); A61K 48/00 (2013.01)] 25 Claims
 
1. A polymeric delivery system comprising polyplexes comprising at least one charged polymer and at least one biologic, wherein the at least one charged polymer comprises a polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer, wherein the polyol monomer comprises glycerol and wherein the polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer has been modified by derivatization of at least a portion of free alcohols of the glycerol to incorporate at least one charged moiety having an opposite charge from a net charge of the at least one biologic, wherein the at least one charged moiety is selected from the group consisting of glutamine, lysine, arginine, sulfate, phosphate, sulfonate, sulfite, carboxy salt, ammonium, choline, phosphocholine, primary amine, secondary amine, tertiary amine, quaternary amine, and carboxylate.