	US 12,440,432 B2
	Methods and compositions for treatment of skin
Burt R. Shaffer, Lloyd Harbor, NY (US); and Steven M. Hernandez, Blue Point, NY (US)
Assigned to Topix Pharmaceuticals, Inc., North Amityville, NY (US)
Filed by Topix Pharmaceuticals, Inc., North Amityville, NY (US)
Filed on Nov. 21, 2018, as Appl. No. 16/198,256.
Claims priority of provisional application 62/589,552, filed on Nov. 21, 2017.
Prior Publication US 2019/0151214 A1, May 23, 2019
Int. Cl. A61K 8/365 (2006.01); A61K 8/06 (2006.01); A61K 8/42 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/17 (2006.01); A61K 31/19 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/14 (2017.01); A61K 47/24 (2006.01); A61P 17/00 (2006.01); A61Q 19/00 (2006.01); A61K 9/127 (2006.01)

CPC A61K 8/365 (2013.01) [A61K 8/06 (2013.01); A61K 8/42 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 31/17 (2013.01); A61K 31/19 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/24 (2013.01); A61P 17/00 (2018.01); A61Q 19/007 (2013.01); A61K 9/127 (2013.01)]

25 Claims

1. A topical formulation comprising (% w/w):

at least 15% alpha hydroxy acid (AHA), wherein the AHA comprises glycolic acid at least 10% urea or a urea derivative,

10.75%-30% potassium hydroxide, and

0.01%-5% hydrolyzed sodium hyaluronate, and

one or more of an exfoliating peptide, or a proteolytic enzyme,

an amino acid mixture, wherein the amino acid mixture consists of water, disodium EDTA, glycine, L-citrulline, L-alanine, L-proline, L-ornithine monohydrochloride, L-arginine, L-glutamic acid, L-histidine, valine, L-lysine, L-aspartic acid, leucine, threonine, tyrosine, DL-phenylalanine, taurine, L-isoleucine, methionine, and serine and wherein the amino acid mixture has a profile of the skin's natural moisturizing factor, and

one or more exfoliating agents comprising mandelic acid.