US 12,440,430 B2
Use of tetrapeptides and functionalised microcapsules as skin penetration carriers
Aimée Vasconcelos Pacheco, Barcelona (ES); Ramona Galatola, Barcelona (ES); and Marisabel Mourelle Mancini, Barcelona (ES)
Assigned to INFINITEC ACTIVOS S L, Barcelona (ES)
Appl. No. 17/759,131
Filed by INFINITEC ACTIVOS S L, Barcelona (ES)
PCT Filed Jan. 21, 2021, PCT No. PCT/EP2021/051252
§ 371(c)(1), (2) Date Jul. 20, 2022,
PCT Pub. No. WO2021/148496, PCT Pub. Date Jul. 29, 2021.
Claims priority of application No. 20382036 (EP), filed on Jan. 23, 2020.
Prior Publication US 2023/0132979 A1, May 4, 2023
Int. Cl. A61K 8/11 (2006.01); A61K 8/49 (2006.01); A61K 8/64 (2006.01); A61K 8/85 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 8/11 (2013.01) [A61K 8/498 (2013.01); A61K 8/64 (2013.01); A61K 8/85 (2013.01); A61Q 19/00 (2013.01)] 18 Claims
 
1. A microcapsule, comprising:
a polymeric shell comprising poly(D,L-lactide-co-glycolide) acid (PLGA),
a first peptide of formula (I)
 
 (I)
 
 (SEQ ID NO: 3-NH2)
 
 D-Arg-Tyr-Orn-Phe-NH2
coupled to said polymeric shell, and
a second peptide selected from the group consisting of a peptide of formula (II) and a peptide of formula (III)
 
 (II)
 
 (SEQ ID NO: 1-NH2)
 
 Lys-Phe-Asn-Leu-Pro-Ala-Gly-Asn-
 
 
 
 Tyr-Lys-Lys-Pro-NH2,
 
 and
 
 
 
 (III)
 
 (SEQ ID NO: 2-OH)
 
 Lys-Thr-Thr-Lys-Ser-OH,
coupled to said polymeric shell.