US 12,440,412 B2
Incubation system for liquid-based incubation of prematurely born infants
Swan Gie Oei, Eindhoven (NL); Franciscus Nicolaas Van De Vosse, Eindhoven (NL); Laurentius Michiel Gerardus Feijs, Eindhoven (NL); Marieke Beatrijs Van Der Hout-Van Der Jagt, Eindhoven (NL); Myrthe Van Der Ven, Eindhoven (NL); Franciscus Leonardus Marie Delbressine, Eindhoven (NL); and Antoine Pascal Oei, Eindhoven (NL)
Assigned to TECHNISCHE UNIVERSITEIT EINDHOVEN, Eindhoven (NL)
Appl. No. 17/599,882
Filed by TECHNISCHE UNIVERSITEIT EINDHOVEN, Eindhoven (NL)
PCT Filed Mar. 30, 2020, PCT No. PCT/EP2020/059012
§ 371(c)(1), (2) Date Sep. 29, 2021,
PCT Pub. No. WO2020/201233, PCT Pub. Date Oct. 8, 2020.
Claims priority of provisional application 62/826,718, filed on Mar. 29, 2019.
Prior Publication US 2022/0192909 A1, Jun. 23, 2022
Int. Cl. A61G 11/00 (2006.01); A01N 1/143 (2025.01)
CPC A61G 11/00 (2013.01) [A01N 1/143 (2025.01); A61M 2240/00 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An incubation system for liquid-based incubation of prematurely born infants, comprising:
an inner chamber forming an amniotic basin containing amniotic fluid, the amniotic basin configured to hold an infant, and the amniotic basin made from a flexible material configured to expand an inner chamber volume in correspondence with growth of the infant;
an outer chamber enclosing the inner chamber, the outer chamber containing a temperature regulation fluid;
a fetal connection port configured to connect with an umbilical cord of the infant, the fetal connection port providing a port in the inner chamber to the infant to provide dialyzation and nutrition compounds to the infant via the umbilical cord;
a fetal control unit coupled to the fetal connection port to control the dialyzation and provided nutrition compounds by monitoring and controlling one or more of a pressure, flow and temperature thereof;
an amniotic fluid circulation unit configured to connect with an inlet/outlet port of the inner chamber, the amniotic fluid circulation unit comprising a pump configured to circulate the amniotic fluid from the inner chamber and through a purification system located outside of the inner chamber; and
a temperature regulation fluid control unit configured to connect with an inlet/outlet port of the outer chamber, the temperature regulation fluid control unit comprising a pump configured to circulate the temperature regulation fluid from the outer chamber and through a heat exchanger system located outside of the outer chamber.