US 12,440,325 B2
Connective tissue to bone interface scaffolds
Dushyanth R. Surakanti, Madison, NJ (US); Adam B. Yanke, Madison, NJ (US); Adam W. Martinez, Madison, NJ (US); Kurt W.S. Klitzke, Madison, NJ (US); Travis E. Entrop, Madison, NJ (US); Dimitrios J. Angelis, Madison, NJ (US); Eric A. Nauman, West Lafayette, IN (US); and Darryl A. Dickerson, Miami, FL (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US); BioEnthesis Inc., Durham, NC (US); and Advanced Regenerative Tech, Inc., Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US); BioEnthesis Inc., Durham, NC (US); and Advanced Regenerative Tech Inc., Lafayette, IN (US)
Filed on Apr. 21, 2023, as Appl. No. 18/305,319.
Application 18/305,319 is a continuation of application No. 17/222,719, filed on Apr. 5, 2021, granted, now 11,654,012.
Application 17/222,719 is a continuation of application No. 17/015,043, filed on Sep. 8, 2020, granted, now 10,966,816, issued on Apr. 6, 2021.
Claims priority of provisional application 63/069,658, filed on Aug. 24, 2020.
Claims priority of provisional application 62/923,470, filed on Oct. 18, 2019.
Prior Publication US 2024/0016598 A1, Jan. 18, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/28 (2006.01); A61F 2/08 (2006.01); A61L 27/36 (2006.01); A61F 2/30 (2006.01)
CPC A61F 2/0811 (2013.01) [A61F 2/2846 (2013.01); A61L 27/3604 (2013.01); A61L 27/3608 (2013.01); A61F 2002/0823 (2013.01); A61F 2002/0876 (2013.01); A61F 2002/2835 (2013.01); A61F 2002/30059 (2013.01); A61F 2002/30448 (2013.01); A61F 2210/0076 (2013.01); A61F 2220/005 (2013.01); A61F 2220/0075 (2013.01); A61F 2250/006 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A flexible, compressible and compliant graft body having a length, a width and a thickness, wherein the thickness is between 4 mm and 6.5 mm and is less than half the length and half the width, the body further comprising:
a first layer of porous demineralized bone extending the length and width of the body; and
a second layer of porous mineralized bone extending along an outer surface of the body that is continuously adjacent to the first layer, wherein the second layer has a constant thickness;
wherein the body has a density that is less than 2.6e-4 g/mm3.