US 12,440,144 B1
Multi-channel brain or cortical activity monitoring and method
Stéphane Bibian, Orange, OH (US); and Tatjana Zikov, Orange, OH (US)
Assigned to NeuroWave Systems Inc., Cleveland, OH (US)
Filed by NeuroWave Systems Inc., Cleveland, OH (US)
Filed on Dec. 12, 2022, as Appl. No. 18/079,126.
Application 18/079,126 is a continuation of application No. 15/867,769, filed on Jan. 11, 2018, granted, now 11,553,869.
Application 15/867,769 is a continuation of application No. 14/330,408, filed on Jul. 14, 2014, abandoned.
Application 14/330,408 is a continuation of application No. 12/628,568, filed on Dec. 1, 2009, granted, now 8,838,226, issued on Sep. 16, 2014.
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/369 (2021.01); A61M 5/172 (2006.01)
CPC A61B 5/369 (2021.01) [A61B 5/4064 (2013.01); A61B 5/4082 (2013.01); A61B 5/4821 (2013.01); A61B 5/6843 (2013.01); A61M 5/1723 (2013.01); A61B 5/7203 (2013.01); A61B 5/7221 (2013.01); A61B 5/7225 (2013.01); A61B 5/7257 (2013.01); A61B 5/726 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of sedating or anesthetizing a subject by determining electroencephelogram (EEG) signal quality with a device for quantifying brain or cortical activity during sedation or anesthesia comprising steps of:
a. sedating or anesthetizing a subject;
b. monitoring the subject with a brain having a left hemisphere and a right hemisphere, the subject under anesthesia or sedation and being monitored with a device for quantifying brain or cortical activity as a function of depth of sedation or anesthesia, the device with at least two measurement electrodes, and at least one reference electrode, the at least two measurement electrodes comprising at least one EEG electrode, having a signal, positioned to monitor left hemisphere brain or cortical activity and at least one EEG electrode, having a signal, positioned to monitor right hemisphere brain or cortical activity of the subject's brain, the reference electrode comprising at least one EEG electrode, each electrode providing an EEG analog signal which is subsequently converted to a digital signal;
c. measuring the brain or cortical activity of both the subject's left and right brain hemispheres essentially simultaneously over a period of time, part of the period of time over which the subject is under sedation or anesthesia;
d. calculating based in part on the digital signals with a processor at least one numerical quantitative electroencephalogram (QEEG) time-series index, respectively, corresponding to the brain or cortical activity as a function of depth of sedation or anesthesia for each of the left and right hemispheres of the subject's brain over the period of time part of which the subject is under sedation or anesthesia resulting in numerical time-series indices for each of the left and right hemispheres of the subject's brain;
e. comparing the numerical time-series indices for each of the left and right hemispheres as a function of depth of sedation or anesthesia; and
f. treating the subject by administering further sedation or anesthesia to the subject based on comparison, by the processor or with a second processor, of the numerical time-series indices for each of the left and right hemispheres corresponding to the brain activity as a function of depth of sedation or anesthesia of the brain region of the subject.