US 12,440,139 B2
System and method for non-invasively monitoring autonomic nerve activity
Peng-Sheng Chen, Indianapolis, IN (US)
Assigned to Indiana University Research and Technology Corporation, Bloomington, IN (US)
Filed by INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, Indianapolis, IN (US)
Filed on May 18, 2022, as Appl. No. 17/747,081.
Application 17/747,081 is a division of application No. 15/490,230, filed on Apr. 18, 2017, granted, now 11,357,432.
Application 15/490,230 is a continuation of application No. PCT/US2015/056419, filed on Oct. 20, 2015.
Claims priority of provisional application 62/158,323, filed on May 7, 2015.
Claims priority of provisional application 62/065,854, filed on Oct. 20, 2014.
Prior Publication US 2022/0273216 A1, Sep. 1, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 5/05 (2021.01); A61B 5/24 (2021.01); A61N 1/04 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01); A61N 1/362 (2006.01); A61N 1/365 (2006.01)
CPC A61B 5/24 (2021.01) [A61B 5/05 (2013.01); A61B 5/4029 (2013.01); A61B 5/6877 (2013.01); A61B 5/725 (2013.01); A61N 1/0456 (2013.01); A61N 1/0476 (2013.01); A61N 1/0504 (2013.01); A61N 1/0551 (2013.01); A61N 1/36017 (2013.01); A61N 1/36053 (2013.01); A61N 1/36031 (2017.08); A61N 1/36034 (2017.08); A61N 1/3627 (2013.01); A61N 1/36592 (2013.01)] 29 Claims
OG exemplary drawing
 
1. A method for monitoring nerve activity in a subject, the method comprising:
amplifying electrical signals received from one or more electrodes of a plurality of electrodes, the one or more electrodes being placed in locations proximate to a subject's skin to generate a plurality of amplified signals;
applying a filter to the plurality of electrical signals to generate a plurality of filtered signals;
identifying, with a signal processor, a skin nerve activity using the plurality of filtered signals;
estimating, with the signal processor, a sympathetic nerve activity using the identified skin nerve activity;
generating a report indicative of the estimated sympathetic nerve activity;
generating, with a signal generator, electrical stimulation: based upon the estimated sympathetic nerve activity, based on manually-input instructions from an operator, and/or intermittently; and
applying the electrical stimulation to the subject with one or more cutaneously-placed electrodes of the plurality of electrodes or with one or more subcutaneously-placed electrodes of the plurality of electrodes,
wherein the electrical stimulation:
is applied with the one or more cutaneously-placed electrodes or the one or more subcutaneously-placed electrodes, at a location other than a vagus nerve, and
remodels a neural structure spaced away from the one or more cutaneously-placed electrodes or the one or more subcutaneously-placed electrodes.