US 12,440,118 B2
System and method for determining arterial input function based on susceptibility contrast in the choroid plexus
Olivia Sobczyk, Etobicoke (CA); Ece Su Sayin, Windsor (CA); David Mikulis, Oakville (CA); Joseph Arnold Fisher, Thornhill (CA); and James Duffin, Toronto (CA)
Assigned to THORNHILL SCIENTIFIC INC., North York (CA)
Filed by THORNHILL SCIENTIFIC INC., North York (CA)
Filed on Feb. 27, 2023, as Appl. No. 18/114,436.
Claims priority of provisional application 63/314,014, filed on Feb. 25, 2022.
Prior Publication US 2023/0270348 A1, Aug. 31, 2023
Int. Cl. A61B 5/055 (2006.01); A61B 5/026 (2006.01); A61B 6/50 (2024.01)
CPC A61B 5/055 (2013.01) [A61B 5/0263 (2013.01); A61B 6/507 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for measuring perfusion metrics comprising:
(a) inducing a change in concentration of deoxyhemoglobin in a subject,
wherein inducing the change in concentration of deoxyhemoglobin comprises:
targeting a first end-tidal partial pressure of oxygen (PETO2) and carbon dioxide (PETCO2) in the subject using a sequential gas delivery device; and
targeting a second PETO2 and PETCO2 in the subject using the sequential gas delivery device;
(b) measuring a set of magnetic signals for a reference voxel corresponding to a region of interest in the subject's choroid plexus, the set of magnetic signals responsive to the change in concentration of deoxyhemoglobin;
(c) calculating an arterial input function based on the set of magnetic signals for the reference voxel; and
(d) outputting the arterial input function at a display.