	US 12,440,101 B2
	Pupilometry with light intensity calibration
Kamran Siminou, Newport Coast, CA (US)
Assigned to Neuroptics, Inc., Irvine, CA (US)
Filed by Neuroptics, Inc., Irvine, CA (US)
Filed on Aug. 10, 2021, as Appl. No. 17/398,106.
Application 17/398,106 is a continuation of application No. PCT/US2020/018003, filed on Feb. 12, 2020.
Claims priority of provisional application 62/804,467, filed on Feb. 12, 2019.
Prior Publication US 2022/0233072 A1, Jul. 28, 2022
Int. Cl. A61B 3/10 (2006.01); A61B 3/00 (2006.01); A61B 3/02 (2006.01); A61B 3/024 (2006.01); A61B 3/12 (2006.01); A61B 3/14 (2006.01)

CPC A61B 3/14 (2013.01) [A61B 3/0008 (2013.01); A61B 3/0041 (2013.01); A61B 2560/0431 (2013.01)]

9 Claims

1. A method of examining a response of one or more pupils of an eye, comprising:

providing a hand-held pupilometer comprising a display, a built-in camera, a central processing unit with a memory comprising an algorithm and a light stimulus source, wherein the light stimulus source can emit light at various intensities;

using the pupilometer to locate the pupil;

using the pupilometer to determine a distance between the pupilometer and the eye by:

emitting a first light of known intensity to the eye;

identifying at least two Perkinje reflections from the eye; and

calculating the distance between the at least two Perkinje reflections to calculate the distance between the pupilometer and the eye;

applying the algorithm to calculate a specific light intensity based on the distance between the pupilometer and the eye and cause the light stimulus source to emit one or more flashes of light at said specific light intensity;

using the built-in camera to record the response of the pupil to the one or more flashes of light; and

displaying on the display data representative of constriction, dilation or shape response of the pupil to the one or more flashes of light.