	US 12,439,925 B2
	Anti-pathogenic activity of a bifunctional peptidoglycan/chitin hydrolase
Camille Allonsius, Antwerp (BE); and Sarah Lebeer, Mortsel (BE)
Assigned to UNIVERSITEIT ANTWERPEN, Antwerp (BE)
Appl. No. 17/285,705
Filed by Universiteit Antwerpen, Antwerp (BE)
PCT Filed Oct. 21, 2019, PCT No. PCT/EP2019/078581 § 371(c)(1), (2) Date Apr. 15, 2021, PCT Pub. No. WO2020/079278, PCT Pub. Date Apr. 23, 2020.
Claims priority of application No. 18201637 (EP), filed on Oct. 19, 2018.
Prior Publication US 2022/0000122 A1, Jan. 6, 2022
Int. Cl. A61K 35/747 (2015.01); A01N 63/22 (2020.01); A01N 63/50 (2020.01); A61K 38/16 (2006.01); A61K 38/47 (2006.01)

CPC A01N 63/50 (2020.01) [A01N 63/22 (2020.01); A61K 38/164 (2013.01); A61K 38/47 (2013.01); C12Y 302/01014 (2013.01)]

16 Claims

1. A method of reducing and/or preventing hyphae formation in a hyphae-forming pathogen, the method comprising contacting the pathogen with a composition consisting of (i) an effective amount of a bifunctional peptidoglycan/chitin hydrolase purified from a supernatant of a Lactobacilliae strain, and (ii) lactic acid, wherein the bifunctional peptidoglycan/chitin hydrolase is major secreted protein 1 (Msp1), and wherein the pathogen contacts the Msp1 and lactic acid.