| CPC A01N 1/143 (2025.01) [A01N 1/122 (2025.01); A61L 2/0047 (2013.01); A61L 2202/21 (2013.01)] | 10 Claims |
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1. An organ preservation apparatus for circulating perfusate in contact with an organ, comprising:
a chamber;
a support platform within the chamber which forms a support for an organ thereon;
a first fluid circuit having a perfusate pump arranged to circulate perfusate into contact with an organ supported on the support platform in the chamber;
a first reservoir arranged to collect perfusate flowing from an organ in the chamber, wherein the first fluid circuit is arranged to return perfusate from the first reservoir through the perfusate pump to an organ located within the chamber; and
a source of UV light positioned within a housing;
a hemispheric UV light transmissive window mounted to the housing;
a UV manifold mounted to the housing and having an internal passageway which expands to a perfusate UV chamber, wherein the internal passageway has an inlet ahead of the perfusate UV chamber, the inlet communicating with the first fluid circuit, and wherein the internal passageway has an outlet after the perfusate UV chamber which communicates with the first fluid circuit, and wherein the hemispheric UV transparent window extends into the perfusate UV chamber, the source of UV light being positioned in the housing to emit radial UV emissions through the hemispheric UV transparent window to pass into the perfusate UV chamber so that perfusate circulating in the first fluid circuit is exposed to UV light from the source of UV light within the perfusate UV chamber to inactivate pathogens in perfusate circulating in the first fluid circuit.
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9. An organ preservation apparatus for circulating perfusate in contact with an organ, comprising:
a chamber;
a support platform within the chamber which forms a support for an organ thereon;
a first fluid circuit having a perfusate pump arranged to circulate perfusate into contact with an organ supported on the support platform in the chamber;
a first reservoir arranged to collect perfusate flowing from an organ in the chamber, wherein the first fluid circuit communicates with said first reservoir to return perfusate through the perfusate pump to an organ located within the chamber;
a dialysis device having a first compartment separated from a second compartment by a dialyzing filter;
a second fluid circuit having a second pump arranged to circulate dialysate from a second reservoir through the first compartment, the dialyzing filter and the second compartment of the dialysis device;
wherein the first fluid circuit is connected to the second compartment of the dialysis device to pass perfusate on one side of the dialyzing filter to exchange wastes across the dialyzing filter from perfusate in the first fluid circuit to dialysate circulating in the second fluid circuit; and
an ion exchange resin arranged in the second fluid circuit and arranged to contact dialysate circulating in the second fluid circuit to exchange ions with dialysate in the second fluid circuit, wherein the ion exchange resin is a weak base anion exchange resin that is preconditioned to capture lactate ions from the dialysate;
a device arranged to apply pathogen inhibiting radiant energy to perfusate circulating in the first fluid circuit, wherein the device arranged to apply pathogen inhibiting radiant energy further comprises:
a source of UV light, and a UV light transmissive window having a first side arranged to receive UV light from the source of UV light, and a second side forming part of the first fluid circuit so that perfusate circulating in the first fluid circuit is exposed to UV light from the source of UV light to inactivate pathogens in perfusate circulating in the first fluid circuit, wherein the UV light transmissive window is hemispherical, such that perfusate flow follows a curved path within the first fluid circuit.
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