US 12,111,325 B2
Analyte detection system, and methods of use related thereto
Christian Pudduck, Norfolk, MA (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Appl. No. 17/268,185
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
PCT Filed Aug. 19, 2019, PCT No. PCT/US2019/047003
§ 371(c)(1), (2) Date Feb. 12, 2021,
PCT Pub. No. WO2020/046609, PCT Pub. Date Mar. 5, 2020.
Claims priority of provisional application 62/723,189, filed on Aug. 27, 2018.
Prior Publication US 2021/0302443 A1, Sep. 30, 2021
Int. Cl. G01N 33/72 (2006.01); G01N 21/31 (2006.01); G01N 27/27 (2006.01)
CPC G01N 33/726 (2013.01) [G01N 21/314 (2013.01); G01N 27/27 (2013.01); G01N 2021/3144 (2013.01)] 14 Claims
OG exemplary drawing
 
1. An analyte detection system for the detection and measurement of various analytes which are present in a patient's liquid test sample, comprising:
a base, the base comprising at least one side, a top surface, and a bottom surface, the base further comprising:
a liquid test sample inlet for receiving a patient's liquid test sample, the liquid test sample inlet being located on the top surface of the base;
a plurality of microchannels located within the base and in fluid communication with the liquid test sample inlet, the plurality of microchannels being located between the top surface and bottom surface of the base;
an electrochemical assay portion; and
a CO-oximetry assay portion, the CO-oximetry assay portion comprising:
a CO-oximetry sensor module, the CO-oximetry sensor module comprising a sample holder configured to hold a volume of the patient's liquid test sample, the sample holder further comprising an optical measurement surface;
a shunt configured to engage the patient's liquid test sample within the sample holder, wherein the shunt is configured to move longitudinally to deposit a predetermined thickness of the patient's liquid test sample on the optical measurement surface, wherein the predetermined thickness is in a range of from about 80 microns to about 160 microns; and
wherein the CO-oximetry sensor module further comprises an actuator for operating the shunt; and
wherein the electrochemical assay portion and the CO-oximetry assay portion are in fluid communication with and connected via the plurality of microchannels.