US 12,111,289 B2
Systems and methods for imaging cortical bone and soft tissue
Jonathan Randall Fincke, Lincoln, MA (US); and Brian W. Anthony, Cambridge, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Appl. No. 17/255,410
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
PCT Filed Jun. 26, 2019, PCT No. PCT/US2019/039279
§ 371(c)(1), (2) Date Dec. 22, 2020,
PCT Pub. No. WO2020/006097, PCT Pub. Date Jan. 2, 2020.
Claims priority of provisional application 62/690,041, filed on Jun. 26, 2018.
Prior Publication US 2021/0215642 A1, Jul. 15, 2021
Int. Cl. G03B 42/06 (2021.01); G01N 29/06 (2006.01); G01N 29/24 (2006.01); G01N 33/12 (2006.01); A61B 5/00 (2006.01); A61B 8/13 (2006.01)
CPC G01N 29/0672 (2013.01) [G01N 29/2418 (2013.01); G01N 33/12 (2013.01); A61B 5/0095 (2013.01); A61B 8/13 (2013.01); G01N 2291/02475 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method for imaging a biological body segment of soft and hard tissues, comprising:
a) setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set, wherein generating simulated time series data employs at least one tissue boundary detection process;
b) collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set of images of the biological body segment; and
c) minimizing the difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment.