US 12,111,286 B2
Ion mobility analysis apparatus
Xiaoqiang Zhang, Shanghai (CN); Keke Wang, Shanghai (CN); and Wenjian Sun, Shanghai (CN)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Filed by Shimadzu Corporation, Kyoto (JP)
Filed on Apr. 4, 2022, as Appl. No. 17/712,506.
Claims priority of application No. 202110429155.7 (CN), filed on Apr. 21, 2021.
Prior Publication US 2022/0341874 A1, Oct. 27, 2022
Int. Cl. G01N 27/622 (2021.01); H01J 49/00 (2006.01); H01J 49/40 (2006.01)
CPC G01N 27/622 (2013.01) [H01J 49/004 (2013.01); H01J 49/40 (2013.01)] 16 Claims
OG exemplary drawing
 
1. An ion mobility analysis apparatus, comprising:
an ion source for continuously generating ions, which contain analyte ions;
a first ion storage zone located downstream of the ion source;
a second ion storage zone located downstream of the ion source; and
an ion mobility analyzer located downstream of the ion source for receiving the ions generated by the ion source and performing mobility analysis;
wherein the ion mobility analyzer comprises an ion inlet, a first channel, a second channel and an ion outlet, wherein after the ions generated by the ion source enter the ion inlet, they pass through the first channel and the second channel successively and leave the ion mobility analyzer from the ion outlet, wherein the first ion storage zone is located at an end of the second channel distal to the ion outlet, and the second ion storage zone is located at an end of the first channel proximal to the ion inlet;
wherein the ion mobility analyzer is configured to scan at least one operating parameter that varies according to time t as a function f(t) in an operating period from t0 to t1, so that ions with different mobilities pass through the ion mobility analyzer sequentially, the function f(t) is a monotonic function of time t, the analyte ions pass through the ion mobility analyzer in an operating parameter range of [f(tA), f(tB)], and t0<tA<tB<t1;
the operating period is repeated multiple times, and in each operating period excluding the first operating period:
in the stage of t0≤t<tA, the analyte ions generated by the ion source in the stage of t0≤t<tA pass through a part of the ion mobility analyzer to enter the first ion storage zone;
in the stage of tB≤t<t1, the analyte ions generated by the ion source in the stage of tB≤t<t1 pass through a part of the ion mobility analyzer to enter the second ion storage zone; and
in the stage of tA≤t≤tB, the analyte ions generated by the ion source in the stage of tA≤t≤tB, the analyte ions stored in the first ion storage zone in the operating period, and the analyte ions stored in the second ion storage zone in a previous operating period pass through the ion mobility analyzer to enter a next stage analysis apparatus or be detected by a detector.